Mercury methylation genes in bacteria and archaea
Two genes required for this mercury methylation have been identified in bacteria and archaea. These genes are the hgcA gene and hgcB, a corrinoid protein that facilitates methyl group transfer to Hg, and a corrinoid protein-associated ferredoxin with two [4Fe-4S] binding motifs involved in generating cob(I)almin, respectively. The invention provides nucleic acid probes and primers for detecting methylmercury and or for assessing mercury methylation potential in environmental, clinical and other samples. The invention also provides antibodies against these proteins, antibodies against these proteins, methods of using the antibodies and methods of biocatalysis.
- Issue Date:
- OSTI Identifier:
- 1464626
- Assignee:
- UT-BATTELLE, LLC (Oak Ridge, TN) ORNL
- Patent Number(s):
- 10,036,072
- Application Number:
- 14/132,906
- Contract Number:
- AC05-00OR22725
- Resource Relation:
- Patent File Date: 2013 Dec 18
- Research Org:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org:
- USDOE
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
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