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Title: Metabolic evolution of Escherichia coli strains that produce organic acids

This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1462996
Assignee:
Myriant Corporation (Woburn, MA) DOEEE
Patent Number(s):
10,017,793
Application Number:
14/491,073
Contract Number:
EE0002878
Resource Relation:
Patent File Date: 2014 Sep 19
Research Org:
Myriant Corporation, Woburn, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY