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Title: Mosaic conserved region HIV immunogenic polypeptides

Abstract

Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

Inventors:
; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1462188
Patent Number(s):
10010606
Application Number:
15/025,733
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM); Oxford University Innovation Limited (Oxford, GB)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 30
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Mosaic conserved region HIV immunogenic polypeptides. United States: N. p., 2018. Web.
Korber, Bette T. M., Hanke, Tomas, & McMichael, Andrew. Mosaic conserved region HIV immunogenic polypeptides. United States.
Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Tue . "Mosaic conserved region HIV immunogenic polypeptides". United States. https://www.osti.gov/servlets/purl/1462188.
@article{osti_1462188,
title = {Mosaic conserved region HIV immunogenic polypeptides},
author = {Korber, Bette T. M. and Hanke, Tomas and McMichael, Andrew},
abstractNote = {Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {7}
}

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Works referenced in this record:

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