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Title: Mosaic conserved region HIV immunogenic polypeptides

Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1462188
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM); Oxford University Innovation Limited (Oxford, GB) LANL
Patent Number(s):
10,010,606
Application Number:
15/025,733
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2014 Sep 30
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

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