Mosaic conserved region HIV immunogenic polypeptides
Abstract
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1462188
- Patent Number(s):
- 10010606
- Application Number:
- 15/025,733
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM); Oxford University Innovation Limited (Oxford, GB)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Sep 30
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Mosaic conserved region HIV immunogenic polypeptides. United States: N. p., 2018.
Web.
Korber, Bette T. M., Hanke, Tomas, & McMichael, Andrew. Mosaic conserved region HIV immunogenic polypeptides. United States.
Korber, Bette T. M., Hanke, Tomas, and McMichael, Andrew. Tue .
"Mosaic conserved region HIV immunogenic polypeptides". United States. https://www.osti.gov/servlets/purl/1462188.
@article{osti_1462188,
title = {Mosaic conserved region HIV immunogenic polypeptides},
author = {Korber, Bette T. M. and Hanke, Tomas and McMichael, Andrew},
abstractNote = {Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {7}
}
Works referenced in this record:
Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005
- Mullins, James I.; Rodrigo, Allen G.; Learn, Gerald H.
- US Patent Document 10/780507; 20050137387
HIVcon: An HIV Immunogen And Uses Thereof
patent-application, October 2010
- Hanke, Tomas; McMichael, Andrew James
- US Patent Application 12/725651; 20100266635
HIV-1 Envelope Polypeptides for HIV Vaccine
patent-application, December 2011
- Duch, Mogens Ryttergaard; Pedersen, Finn Skou; Bahrami, Shervin
- US Patent Application 13/060564; 20110305749
Polyvalent Vaccine
patent-application, September 2012
- Korber, Bette T.; Perkins, Simon; Bhattacharya, Tammoy
- US Patent Application 13/399963; 20120231028
Characterization of Full-Length HIV Type 1 Subtype C Sequences from South Africa
journal, November 2001
- van Harmelen, Joanne; Williamson, Carolyn; Kim, Bohye
- AIDS Research and Human Retroviruses, Vol. 17, Issue 16, p. 1527-1531
Adjuvants for human vaccines—current status, problems and future prospects
journal, January 1995
- Gupta, Rajesh K.; Siber, George R.
- Vaccine, Vol. 13, Issue 14, p. 1263-1276
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
- Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
- Nature Medicine, Vol. 16, Issue 3, p. 319-323
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
- Fischer, Will; Perkins, Simon; Theiler, James
- Nature Medicine, Vol. 13, Issue 1, p. 100-106
HIV-1: From escapism to conservatism
journal, November 2011
- Hanke, Tomáš; McMichael, Andrew J.
- European Journal of Immunology, Vol. 41, Issue 12, p. 3390-3393
Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
journal, October 2007
- Létourneau, Sven; Im, Eung-Jun; Mashishi, Tumelo
- PLoS ONE, Vol. 2, Issue 10, Article No. e984
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
- Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
- Nature Medicine, Vol. 16, Issue 3, p. 324-328