Engineering microbes and metabolic pathways for the production of ethylene glycol
Abstract
The invention relates to recombinant cells and their use in the production of ethylene glycol.
- Inventors:
- Issue Date:
- Research Org.:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1457726
- Patent Number(s):
- 9994876
- Application Number:
- 14/864,493
- Assignee:
- Massachusetts Institute of Technology (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AR0000059
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Sep 24
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Stephanopoulos, Gregory, Pereira, Brian, De Mey, Marjan, Dugar, Deepak, and Avalos, Jose Luis. Engineering microbes and metabolic pathways for the production of ethylene glycol. United States: N. p., 2018.
Web.
Stephanopoulos, Gregory, Pereira, Brian, De Mey, Marjan, Dugar, Deepak, & Avalos, Jose Luis. Engineering microbes and metabolic pathways for the production of ethylene glycol. United States.
Stephanopoulos, Gregory, Pereira, Brian, De Mey, Marjan, Dugar, Deepak, and Avalos, Jose Luis. Tue .
"Engineering microbes and metabolic pathways for the production of ethylene glycol". United States. https://www.osti.gov/servlets/purl/1457726.
@article{osti_1457726,
title = {Engineering microbes and metabolic pathways for the production of ethylene glycol},
author = {Stephanopoulos, Gregory and Pereira, Brian and De Mey, Marjan and Dugar, Deepak and Avalos, Jose Luis},
abstractNote = {The invention relates to recombinant cells and their use in the production of ethylene glycol.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {6}
}
Works referenced in this record:
A New Enzyme, D -Ketohexose 3-Epimerase, from Pseudomonas sp. ST-24
journal, January 1993
- Izumori, Ken; Khan, Anisur Rahman; Okaya, Hiroaki
- Bioscience, Biotechnology, and Biochemistry, Vol. 57, Issue 6, p. 1037-1039
Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 å resolution
journal, November 1995
- Parsons, M. R.; Convery, M. A.; Wilmot, C. M.
- Structure, Vol. 3, Issue 11, p. 1171-1184
Method for the Preparation of Diols
patent-application, December 2011
- Soucaille, Philippe; Boisart, Cedric
- US Patent Application 13/169703; 20110294178
Microorganisms and Methods for the Production of Ethylene Glycol
patent-application, December 2011
- Osterhout, Robin E.; Pharkya, Priti; Burgard, Anthony P.
- US Patent Application 13/086295; 20110312049
A Molecular View of Microbial Diversity and the Biosphere
journal, May 1997
- Pace, N. R.
- Science, Vol. 276, Issue 5313, p. 734-740
Method of producing L-serine by fermentation
patent, March 2000
- Suga, Mikiko; Sugimoto, Masakazu; Osumi, Tsuyoshi
- US Patent Document 6,037,154
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
journal, February 1997
- Anderson, M. M.; Hazen, S. L.; Hsu, F. F.
- Journal of Clinical Investigation, Vol. 99, Issue 3, p. 424-432
Metabolic Engineering of Lactobacillus plantarum for Production of L-Ribulose
journal, September 2007
- Helanto, M.; Kiviharju, K.; Leisola, M.
- Applied and Environmental Microbiology, Vol. 73, Issue 21, p. 7083-7091
Enzymatic Characterization of an Amine Oxidase from Arthrobacter sp. Used to Measure Phosphatidylethanolamine
journal, October 2008
- Ota, Hiroko; Tamezane, Hideto; Sasano, Yoshie
- Bioscience, Biotechnology, and Biochemistry, Vol. 72, Issue 10, p. 2732-2738
The enzymatic decarboxylation of hydroxypyruvate associated with purified pyruvate decarboxylase from wheat germ
journal, February 1985
- Davies, D.D.; Asker, H.
- Phytochemistry, Vol. 24, Issue 2, p. 231-234
Nucleotide sequences that encode deregulated phosphoglycerate dehydrogenases of coryneform bacteria and method for producing L-serine
patent, June 2010
- Eggeling, Lothar; Peters-Wendisch, Petra; Netzer, Roman
- US Patent Document 7,732,176
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
journal, September 2010
- Ajikumar, P. K.; Xiao, W.-H.; Tyo, K. E. J.
- Science, Vol. 330, Issue 6000, p. 70-74
Production of Xylitol From a Mixture of Hemicellulosic Sugars
patent-application, August 2013
- Zhao, Huimin; Nair, Nikhil Unni; Racine, Michael
- US Patent Application 13/877803; 20130217070
The aldA gene of Escherichia coli is under the control of at least three transcriptional regulators
journal, June 1997
- Limon, A.; Hidalgo, E.; Aguilar, J.
- Microbiology, Vol. 143, Issue 6, p. 2085-2095
Engineering yeasts for xylose metabolism
journal, June 2006
- Jeffries, Thomas W.
- Current Opinion in Biotechnology, Vol. 17, Issue 3, p. 320-326
The nonoxidative decarboxylation of hydroxypyruvate in mammalian systems
journal, May 1964
- Hedrick, Jerry L.; Sallach, H. J.
- Archives of Biochemistry and Biophysics, Vol. 105, Issue 2, p. 261-269
Ethanolamine Production by Fermentation
patent-application, December 2009
- Soucaille, Philippe; Figge, Rainer
- US Patent Application 12/302726; 20090325245
Bacterium capable of fermenting glucose, mannose and xylose simultaneously, and method for production of bioethanol using the bacterium
patent, February 2013
- Yanase, Hideshi; Okamoto, Kenji
- US Patent Document 8,383,377
Microbial Synthesis of D-1,2,4-Butanetriol
patent-application, March 2011
- Frost, John W.; Niu, Wei
- US Patent Application 12/374367; 20110076730
Engineering Microbes and Metabolic Pathways for the Production of Ethylene Glycol
patent-application, November 2013
- Stephanopoulos, Gregory; Pereira, Brian; De Mey, Marjan
- US Patent Application 13/774212; 20130316416
Development of Efficient Xylose Fermentation in Saccharomyces cerevisiae: Xylose Isomerase as a Key Component
book, January 2007
- van Maris, Antonius J. A.; Winkler, Aaron A.; Kuyper, Marko
- Biofuels, p. 179-204
Ethanolamine oxidase from the blowfly, Phormia regina (diptera: insecta)
journal, February 1973
- Kulkarni, A. P.; Hodgson, E.
- Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 44, Issue 2, p. 407-422
Plants Synthesize Ethanolamine by Direct Decarboxylation of Serine Using a Pyridoxal Phosphate Enzyme
journal, July 2001
- Rontein, Denis; Nishida, Ikuo; Tashiro, Gen
- Journal of Biological Chemistry, Vol. 276, Issue 38, p. 35523-35529
L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose.
journal, August 1991
- Badia, J.; Gimenez, R.; Baldomá, L.
- Journal of Bacteriology, Vol. 173, Issue 16, p. 5144-5150
Process for the biological production of 1,3-propanediol with high yield
patent, May 2008
- Cervin, Marguerite A.; Soucaille, Phillipe; Valle, Fernando
- US Patent Document 7,371,558