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Title: Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same

Abstract

A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: ##STR00001## wherein R.sub.1-R.sub.7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
Univ. of Southern California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1457028
Patent Number(s):
9,987,380
Application Number:
13/549,309
Assignee:
University of Southern California (Los Angeles, CA) DOESC
DOE Contract Number:  
SC0002353
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Jul 13
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Li, Zibo, Gabbai, Francois P., Conti, Peter S., Hudnall, Todd W., Lin, Tzu-Pin, Liu, Shuanglong, and Huang, Chiun-Wei. Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same. United States: N. p., 2018. Web.
Li, Zibo, Gabbai, Francois P., Conti, Peter S., Hudnall, Todd W., Lin, Tzu-Pin, Liu, Shuanglong, & Huang, Chiun-Wei. Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same. United States.
Li, Zibo, Gabbai, Francois P., Conti, Peter S., Hudnall, Todd W., Lin, Tzu-Pin, Liu, Shuanglong, and Huang, Chiun-Wei. Tue . "Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same". United States. https://www.osti.gov/servlets/purl/1457028.
@article{osti_1457028,
title = {Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same},
author = {Li, Zibo and Gabbai, Francois P. and Conti, Peter S. and Hudnall, Todd W. and Lin, Tzu-Pin and Liu, Shuanglong and Huang, Chiun-Wei},
abstractNote = {A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: ##STR00001## wherein R.sub.1-R.sub.7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {6}
}

Patent:

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