Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof

Polsky, Ronen; Miller, Philip Rocco; Edwards, Thayne L.

Title: Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof

Abstract

The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.

Inventors:: Polsky, Ronen; Miller, Philip Rocco; Edwards, Thayne L.

Issue Date:: 2018-06-05

Research Org.:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1457027

Patent Number(s):: 9987427

Application Number:: 14/746,301

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/150022 - {for capillary blood or interstitial fluid}
A61B5/150984 - {Microneedles or microblades}
A61B5/155 - {Devices} specially adapted for continuous or multiple sampling, e.g. at predetermined intervals {
A61B5/157 - {Devices} characterised by integrated means for measuring characteristics of blood

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M2005/1726 - {the body parameters being measured at, or proximate to, the infusion site}
A61M2037/003 - {having a lumen}
A61M2037/0061 - {Methods for using microneedles}
A61M2202/048 - Anaesthetics
A61M2202/30 - Vaccines
A61M2205/8206 - battery-operated
A61M37/0015 - {by using microneedles}
A61M5/1723 - {using feedback of body parameters, e.g. blood-sugar, pressure

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Jun 22

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Polsky, Ronen, Miller, Philip Rocco, and Edwards, Thayne L. Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof.  United States: N. p., 2018. 
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                    Polsky, Ronen, Miller, Philip Rocco, & Edwards, Thayne L. Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof.  United States.

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                    Polsky, Ronen, Miller, Philip Rocco, and Edwards, Thayne L. Tue .  
        "Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof".  United States.  https://www.osti.gov/servlets/purl/1457027.

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@article{osti_1457027,

  title        = {Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof},

  author       = {Polsky, Ronen and Miller, Philip Rocco and Edwards, Thayne L.},

  abstractNote = {The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2018},

  month        = {6}

}

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Coated microneedles for transdermal delivery
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Gill, Harvinder S.; Prausnitz, Mark R.
Journal of Controlled Release, Vol. 117, Issue 2, p. 227-237
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Microneedle-based self-powered glucose sensor
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Valdés-Ramírez, Gabriela; Li, Ya-Chieh; Kim, Jayoung
Electrochemistry Communications, Vol. 47, p. 58-62
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Arrigan, Damien W. M.
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Lithographically Defined Three-Dimensional Graphene Structures
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Xiao, Xiaoyin; Beechem, Thomas E.; Brumbach, Michael T.
ACS Nano, Vol. 6, Issue 4, p. 3573-3579
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Amperometric biosensors for clinical and therapeutic drug monitoring: a review
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Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability
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Microneedle Arrays for Biosensing and Drug Delivery
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Active needle devices with integrated functionality
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System and methods for optical sensing and drug delivery using microneedles
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Hoarau, Carine; Li, Li; Batchelder, Keith
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Fabrication process for tall, sharp, hollow, high aspect ratio polymer microneedles on a platform
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Ceyssens, Frederik; Chaudhri, Buddhadev Paul; Van Hoof, Chris
Journal of Micromechanics and Microengineering, Vol. 23, Issue 7, Article No. 075023
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Some Recent Designs and Developments of Screen‐Printed Carbon Electrochemical Sensors/Biosensors for Biomedical, Environmental, and Industrial Analyses
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Hart, John P.; Crew, Adrian; Crouch, Eric
Analytical Letters, Vol. 37, Issue 5, p. 789-830
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Cancer Detection: Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy (Adv. Healthcare Mater. 8/2015)
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Keum, Do Hee; Jung, Ho Sang; Wang, Taejun
Advanced Healthcare Materials, Vol. 4, Issue 8
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Electrically Addressable Cell Immobilization Using Phenylboronic Acid Diazonium Salts
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Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
Angewandte Chemie International Edition, Vol. 47, Issue 14, p. 2631-2634
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Mechanism of fluid infusion during microneedle insertion and retraction
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Martanto, Wijaya; Moore, Jason S.; Couse, Tracey
Journal of Controlled Release, Vol. 112, Issue 3, p. 357-361
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Development of Blood Extraction System for Health Monitoring System
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Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Uetsuji, Yasutomo
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Collection of Analytes from Microneedle Patches
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Analytical Chemistry, Vol. 86, Issue 21, p. 10520-10523
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Microneedle arrays for biosensing and drug delivery
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Wang, Joseph; Windmiller, Joshua Ray; Narayan, Roger
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Effect of microneedles shape on skin penetration and minimally invasive continuous glucose monitoring in vivo
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Chua, Beelee; Desai, Shashi P.; Tierney, Michael J.
Sensors and Actuators A: Physical, Vol. 203, p. 373-381
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Minimally Invasive Extraction of Dermal Interstitial Fluid for Glucose Monitoring Using Microneedles
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Wang, Ping M.; Cornwell, Megan; Prausnitz, Mark R.
Diabetes Technology & Therapeutics, Vol. 7, Issue 1, p. 131-141
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Surface Modification and Characterization of Polycarbonate Microdevices for Capture of Circulating Biomarkers, Both in Vitro and in Vivo
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Yeow, Bernard; Coffey, Jacob W.; Muller, David A.
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All-solid-state potassium-selective electrode using graphene as the solid contact
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Li, Fenghua; Ye, Junjin; Zhou, Min
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Electrochemical detection of nucleic acid hybridization
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Development of an all-solid-state potassium ion-selective electrode using graphene as the solid-contact transducer
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Ping, Jianfeng; Wang, Yixian; Wu, Jian
Electrochemistry Communications, Vol. 13, Issue 12, p. 1529-1532
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Diazonium-Functionalized Horseradish Peroxidase Immobilized via Addressable Electrodeposition: Direct Electron Transfer and Electrochemical Detection
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Polsky, Ronen; Harper, Jason C.; Dirk, Shawn M.
Langmuir, Vol. 23, Issue 2, p. 364-366
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Microfabricated Microneedles for Gene and Drug Delivery
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McAllister, Devin V.; Allen, Mark G.; Prausnitz, Mark R.
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Analytical instruments, biosensors and methods thereof
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Mansouri, Sohrab; Cosofret, Vasile; Xu, Clarke
US Patent Document 6,652,720
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Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding
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Corrie, Simon R.; Fernando, Germain J. P.; Crichton, Michael L.
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Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches
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Olatunji, Ololade; Das, Diganta B.; Garland, Martin J.
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A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue
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Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.
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Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method
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Verbaan, F. J.; Bal, S. M.; van den Berg, D. J.
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Biosensors for real-time in vivo measurements
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Wilson, George S.; Gifford, Raeann
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Wearable and Portable eHealth Systems
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Gatzoulis, Loukianos; Iakovidis, Ilias
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Possibilities and limitations in miniaturized sensor design for uric acid
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Bravo, Roberto; Hsueh, ChenChan; Brajter-Toth, Anna
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Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
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Heien, Michael L. A. V.; Phillips, Paul E. M.; Stuber, Garret D.
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Effect of Microneedle Design on Pain in Human Volunteers
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Gill, Harvinder S.; Denson, Donald D.; Burris, Brett A.
The Clinical Journal of Pain, Vol. 24, Issue 7, p. 585-594
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Application of a Waist Belt for an Absorbent Article
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Bogdanova, Jenny; Gustin Bergstrom, Maria; Kovacic, Emilia
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Early circulating biomarker detection using a wearable microprojection array skin patch
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Coffey, Jacob W.; Corrie, Simon R.; Kendall, Mark A. F.
Biomaterials, Vol. 34, Issue 37, p. 9572-9583
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Electrochemical biosensors: Towards point-of-care cancer diagnostics
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Wang, Joseph
Biosensors and Bioelectronics, Vol. 21, Issue 10, p. 1887-1892
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Maleimide-Activated Aryl Diazonium Salts for Electrode Surface Functionalization with Biological and Redox-Active Molecules
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Harper, Jason C.; Polsky, Ronen; Wheeler, David R.
Langmuir, Vol. 24, Issue 5, p. 2206-2211
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Chitin Microneedles for an Easy-to-Use Tuberculosis Skin Test
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Jin, Jungho; Reese, Valerie; Coler, Rhea
Advanced Healthcare Materials, Vol. 3, Issue 3, p. 349-353
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Nucleic Acid-Functionalized Pt Nanoparticles: Catalytic Labels for the Amplified Electrochemical Detection of Biomolecules
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Polsky, Ronen; Gill, Ron; Kaganovsky, Lubov
Analytical Chemistry, Vol. 78, Issue 7, p. 2268-2271
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Biological application of microelectrode arrays in drug discovery and basic research
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Stett, Alfred; Egert, Ulrich; Guenther, Elke
Analytical and Bioanalytical Chemistry, Vol. 377, Issue 3, p. 486-495
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Transcorneal drug-release system
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Eicher, Joachim; Zierenberg, Bernd
US Patent Document 6,132,755
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Miller, Philip R.; Skoog, Shelby A.; Edwards, Thayne L.
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Stationary phase deposition based on onium salts
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Wheeler, David R.; Lewis, Patrick R.; Dirk, Shawn M.
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Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol
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Pérennès, F.; Marmiroli, B.; Matteucci, M.
Journal of Micromechanics and Microengineering, Vol. 16, Issue 3, p. 473-479
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Methods and devices for carrying out chemical reactions
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Gordon, Gary B.; Dellinger, Douglas J.
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Design, Development, and Evaluation of a Novel Microneedle Array-based Continuous Glucose Monitor
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Jina, Arvind; Tierney, Michael J.; Tamada, Janet A.
Journal of Diabetes Science and Technology, Vol. 8, Issue 3, p. 483-487
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Targeted, Needle-Free Vaccinations in Skin using Multilayered, Densely-Packed Dissolving Microprojection Arrays
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Raphael, Anthony P.; Prow, Tarl W.; Crichton, Michael L.
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Packaging of electro-microfluidic devices
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Benavides, Gilbert L.; Galambos, Paul C.; Emerson, John A.
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Multifunctional thin film surface
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Brozik, Susan M.; Harper, Jason C.; Polsky, Ronen
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Silicon micromachined hollow microneedles for transdermal liquid transport
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Gardeniers, H. J. G. E.; Luttge, R.; Berenschot, E. J. W.
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Method for forming hollow out-of-plane microneedles and devices formed hereby
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Zimmermann, Stefan; Stoeber, Boris; Liepmann, Dorian
US Patent Application 11/117641; 20060025717
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Hypodermic-needle-like hollow polymer microneedle array using UV lithography into micromolds
conference, January 2011

Wang, Po-Chun; Paik, Seung-Joon; Kim, Jooncheol
2011 IEEE 24th International Conference on Micro Electro Mechanical Systems
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Review: Carbon nanotube based electrochemical sensors for biomolecules
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Jacobs, Christopher B.; Peairs, M. Jennifer; Venton, B. Jill
Analytica Chimica Acta, Vol. 662, Issue 2, p. 105-127
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Ion-Selective Electrodes with Three-Dimensionally Ordered Macroporous Carbon as the Solid Contact
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Lai, Chun-Ze; Fierke, Melissa A.; Stein, Andreas
Analytical Chemistry, Vol. 79, Issue 12, p. 4621-4626
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Physiological and Psychological Fatigue in Extreme Conditions: The Military Example
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Weeks, Sharon R.; McAuliffe, Caitlin L.; DuRussel, David
PM&R, Vol. 2, Issue 5, p. 438-441
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Fabrication of a hollow needle structure by dicing, wet etching and metal deposition
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Shikida, Mitsuhiro; Hasada, Takehiko; Sato, Kazuo
Journal of Micromechanics and Microengineering, Vol. 16, Issue 10, p. 2230-2239
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Capture of the Circulating Plasmodium falciparum Biomarker HRP2 in a Multiplexed Format, via a Wearable Skin Patch
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Lee, Khai Tuck; Muller, David A.; Coffey, Jacob W.
Analytical Chemistry, Vol. 86, Issue 20, p. 10474-10483
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Physiological and Psychological Fatigue in Extreme Conditions: Overtraining and Elite Athletes
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Purvis, Dianna; Gonsalves, Stephen; Deuster, Patricia A.
PM&R, Vol. 2, Issue 5, p. 442-450
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An optimized hollow microneedle for minimally invasive blood extraction
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Li, Cheng Guo; Lee, Chang Yeol; Lee, Kwang
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Epidermal Electronics
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Kim, D.-H.; Lu, N.; Ma, R.
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Multifunctional Electrode Arrays: Towards a Universal Detection Platform
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Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
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Mediated electrocatalytic oxidation of bioanalytes and biosensing of glutamate using functionalized multiwall carbon nanotubes-biopolymer nanocomposite
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Chakraborty, Sudip; Raj, C. Retna
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Harper, Jason C.; Polsky, Ronen; Dirk, Shawn M.
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Two Photon Polymerization of Polymer–Ceramic Hybrid Materials for Transdermal Drug Delivery
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Ovsianikov, A.; Chichkov, B.; Mente, P.
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Sharp tipped plastic hollow microneedle array by microinjection moulding
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Yung, K. L.; Xu, Yan; Kang, Chunlei
Journal of Micromechanics and Microengineering, Vol. 22, Issue 1, Article No. 015016
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Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection
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Vazquez, Patricia; Herzog, Grégoire; O’Mahony, Conor
Sensors and Actuators B: Chemical, Vol. 201, p. 572-578
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Process for derivatizing carbon nanotubes with diazonium species
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Tour, James M.; Bahr, Jeffrey L.; Yang, Jiping
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A fully automated immunoassay from whole blood on a disc
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Lee, Beom Seok; Lee, Jung-Nam; Park, Jong-Myeon
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Emerging synergy between nanotechnology and implantable biosensors: A review
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Vaddiraju, Santhisagar; Tomazos, Ioannis; Burgess, Diane J.
Biosensors and Bioelectronics, Vol. 25, Issue 7, p. 1553-1565
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Advances in Interfacial Design for Electrochemical Biosensors and Sensors: Aryl Diazonium Salts for Modifying Carbon and Metal Electrodes
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Gooding, J. Justin
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Covalent modification of carbon electrodes for voltammetric differentiation of dopamine and ascorbic acid
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Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
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Park, Jung-Hwan; Allen, Mark G.; Prausnitz, Mark R.
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Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique
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Wang, Po-Chun; Wester, B. A.; Rajaraman, S.
2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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Title: Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof

Abstract

Citation Formats

Arrays of hollow out-of-plane microneedles for drug delivery journal, June 2005

Integrated Microcapillary for Sample-to-Answer Nucleic Acid Pretreatment, Amplification, and Detection journal, October 2014

Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy journal, February 2015

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A disposable “intelligent mosquito” with a reversible sampling mechanism using the volume-phase transition of a gel journal, March 2002

Surface Modified Microprojection Arrays for the Selective Extraction of the Dengue Virus NS1 Protein As a Marker for Disease journal, March 2012

Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition journal, October 2012

Preliminary technological assessment of microneedles-based dry electrodes for biopotential monitoring in clinical examinations journal, June 2012

Microdialysis Microneedles for Continuous Medical Monitoring journal, March 2005

Monitoring Method and/or Apparatus patent-application, May 2011

Two-photon polymerization of microneedles for transdermal drug delivery journal, March 2010

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A microfabricated electrode with hollow microneedles for ECG measurement journal, April 2009

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Electrochemical Glucose Biosensors journal, February 2008

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A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA journal, December 2011

Ion-Selective Electrodes Using Carbon Nanotubes as Ion-to-Electron Transducers journal, February 2008

Dissolving polymer microneedle patches for influenza vaccination journal, July 2010

The MiniMed Continuous Glucose Monitoring System journal, December 2000

Nanomaterials meet microfluidics journal, January 2011

Microneedle device for extraction and sensing of bodily fluids patent, March 2008

Insertion Force Estimation of Various Microneedle Array-type Structures Fabricated by a Microstereolithography Apparatus conference, October 2006

Integrated Intra-Dermal Delivery, Diagnostic and Communication System patent-application, July 2009

Advanced Carbon Electrode Materials for Molecular Electrochemistry journal, July 2008

Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected journal, May 2014

Lack of Pain Associated with Microfabricated Microneedles journal, January 2001

Precise Microinjection into Skin Using Hollow Microneedles journal, May 2006

Microneedle devices and methods of manufacture patent, June 2005

Microneedles for transdermal drug delivery journal, March 2004

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics journal, December 1997

Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm journal, January 2014

Microneedle arrays for biosensing and drug delivery patent, August 2017

Lithographically Defined Porous Carbon Electrodes journal, December 2009

Method and apparatus for the transdermal administration of a substance patent-application, October 2003

Electrochemical Method and Sensor for the Detection of Traces of Explosives patent-application, July 2007

Voltametric analysis apparatus and method patent, June 1993

Biocompatibility of an Electrochemical Sensor for Continuous Glucose Monitoring in Subcutaneous Tissue journal, February 2005

Tapered Conical Polymer Microneedles Fabricated Using an Integrated Lens Technique for Transdermal Drug Delivery journal, May 2007

Use of Microneedle Array Devices for Continuous Glucose Monitoring: A Review journal, January 2013

Microneedle array for transdermal biological fluid extraction and in situ analysis journal, September 2004

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications journal, January 2008

Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine journal, May 2013

Lithographically defined microporous carbon structures patent, January 2013

Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch journal, August 2013

Combination ion-selective electrode with a replaceable sensing membrane patent, June 2002

Bicomponent Microneedle Array Biosensor for Minimally-Invasive Glutamate Monitoring journal, September 2011

A tapered hollow metallic microneedle array using backside exposure of SU-8 journal, February 2004

A microneedle-based glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization conference, January 2003

Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis journal, January 2012

Electrochemical affinity assay patent, August 2001

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles journal, January 2011

Microneedle-Based Transdermal Sensor for On-Chip Potentiometric Determination of K+ journal, December 2013

Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects journal, January 2006

Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration journal, July 2013

Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force journal, August 2004

A Novel Method for Monolithic Fabrication of Polymer Microneedles on a Platform for Transdermal Drug Delivery conference, July 2013

Poly vinyl alcohol re-usable masters for microneedle replication journal, April 2009

A Minimally Invasive System for Glucose Area Under the Curve Measurement Using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with Oral Glucose Tolerance Tests in Subjects With and Without Diabetes journal, June 2012

Point of Care Diagnostics: Status and Future journal, December 2011

Electrochemical assembly of organic molecules by the reduction of iodonium salts patent, June 2009

A Bubble-Mediated Intelligent Microscale Electrochemical Device for Single-Step Quantitative Bioassays journal, April 2014

Microinfusion Using Hollow Microneedles journal, January 2006

Method for grafting and growing a conductive organic film on a surface patent-application, December 2004

Selective Immobilization of DNA and Antibody Probes on Electrode Arrays: Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform journal, July 2007

Replaceable Microneedle Cartridge for Biomedical Monitoring patent-application, September 2011

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing journal, March 2011

Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats journal, May 2005

Dexcom G4AP: An Advanced Continuous Glucose Monitor for the Artificial Pancreas journal, November 2013

Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique journal, May 2010

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process journal, March 2009

Fabrication, Characterization, and Application of Boron-Doped Diamond Microelectrodes for in Vivo Dopamine Detection journal, November 2007

Method for grafting and growing a conductive organic film on a surface patent, June 2010

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin journal, February 2007

Screen-Printable Sol−Gel Enzyme-Containing Carbon Inks journal, January 1996

Microneedles for drug and vaccine delivery journal, November 2012

Arrays of hollow out-of-plane microneedles for drug delivery
journal, June 2005

Integrated Microcapillary for Sample-to-Answer Nucleic Acid Pretreatment, Amplification, and Detection
journal, October 2014

Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy
journal, February 2015

Wearable Electrochemical Sensors and Biosensors: A Review
journal, September 2012

A disposable “intelligent mosquito” with a reversible sampling mechanism using the volume-phase transition of a gel
journal, March 2002

Surface Modified Microprojection Arrays for the Selective Extraction of the Dengue Virus NS1 Protein As a Marker for Disease
journal, March 2012

Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition
journal, October 2012

Preliminary technological assessment of microneedles-based dry electrodes for biopotential monitoring in clinical examinations
journal, June 2012

Microdialysis Microneedles for Continuous Medical Monitoring
journal, March 2005

Monitoring Method and/or Apparatus
patent-application, May 2011

Two-photon polymerization of microneedles for transdermal drug delivery
journal, March 2010

Medical prototyping using two photon polymerization
journal, December 2010

Fluidic medical devices and uses thereof
patent-application, November 2006

A microfabricated electrode with hollow microneedles for ECG measurement
journal, April 2009

Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator
journal, January 2011

Electrochemical Glucose Biosensors
journal, February 2008

Review of analytical figures of merit of sensors and biosensors in clinical applications
journal, November 2010

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA
journal, December 2011

Ion-Selective Electrodes Using Carbon Nanotubes as Ion-to-Electron Transducers
journal, February 2008

Dissolving polymer microneedle patches for influenza vaccination
journal, July 2010

The MiniMed Continuous Glucose Monitoring System
journal, December 2000

Nanomaterials meet microfluidics
journal, January 2011

Microneedle device for extraction and sensing of bodily fluids
patent, March 2008

Insertion Force Estimation of Various Microneedle Array-type Structures Fabricated by a Microstereolithography Apparatus
conference, October 2006

Integrated Intra-Dermal Delivery, Diagnostic and Communication System
patent-application, July 2009

Advanced Carbon Electrode Materials for Molecular Electrochemistry
journal, July 2008

Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected
journal, May 2014

Lack of Pain Associated with Microfabricated Microneedles
journal, January 2001

Precise Microinjection into Skin Using Hollow Microneedles
journal, May 2006

Microneedle devices and methods of manufacture
patent, June 2005

Microneedles for transdermal drug delivery
journal, March 2004

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics
journal, December 1997

Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm
journal, January 2014

Microneedle arrays for biosensing and drug delivery
patent, August 2017

Lithographically Defined Porous Carbon Electrodes
journal, December 2009

Method and apparatus for the transdermal administration of a substance
patent-application, October 2003

Electrochemical Method and Sensor for the Detection of Traces of Explosives
patent-application, July 2007

Voltametric analysis apparatus and method
patent, June 1993

Biocompatibility of an Electrochemical Sensor for Continuous Glucose Monitoring in Subcutaneous Tissue
journal, February 2005

Tapered Conical Polymer Microneedles Fabricated Using an Integrated Lens Technique for Transdermal Drug Delivery
journal, May 2007

Use of Microneedle Array Devices for Continuous Glucose Monitoring: A Review
journal, January 2013

Microneedle array for transdermal biological fluid extraction and in situ analysis
journal, September 2004

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008

Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine
journal, May 2013

Lithographically defined microporous carbon structures
patent, January 2013

Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch
journal, August 2013

Combination ion-selective electrode with a replaceable sensing membrane
patent, June 2002

Bicomponent Microneedle Array Biosensor for Minimally-Invasive Glutamate Monitoring
journal, September 2011

A tapered hollow metallic microneedle array using backside exposure of SU-8
journal, February 2004

A microneedle-based glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization
conference, January 2003

Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis
journal, January 2012

Electrochemical affinity assay
patent, August 2001

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles
journal, January 2011

Microneedle-Based Transdermal Sensor for On-Chip Potentiometric Determination of K⁺
journal, December 2013

Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects
journal, January 2006

Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
journal, July 2013

Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force
journal, August 2004

A Novel Method for Monolithic Fabrication of Polymer Microneedles on a Platform for Transdermal Drug Delivery
conference, July 2013

Poly vinyl alcohol re-usable masters for microneedle replication
journal, April 2009

A Minimally Invasive System for Glucose Area Under the Curve Measurement Using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with Oral Glucose Tolerance Tests in Subjects With and Without Diabetes
journal, June 2012

Point of Care Diagnostics: Status and Future
journal, December 2011

Electrochemical assembly of organic molecules by the reduction of iodonium salts
patent, June 2009

A Bubble-Mediated Intelligent Microscale Electrochemical Device for Single-Step Quantitative Bioassays
journal, April 2014

Microinfusion Using Hollow Microneedles
journal, January 2006

Method for grafting and growing a conductive organic film on a surface
patent-application, December 2004

Selective Immobilization of DNA and Antibody Probes on Electrode Arrays: Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform
journal, July 2007

Replaceable Microneedle Cartridge for Biomedical Monitoring
patent-application, September 2011

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
journal, March 2011

Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats
journal, May 2005

Dexcom G4AP: An Advanced Continuous Glucose Monitor for the Artificial Pancreas
journal, November 2013

Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique
journal, May 2010

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process
journal, March 2009

Fabrication, Characterization, and Application of Boron-Doped Diamond Microelectrodes for in Vivo Dopamine Detection
journal, November 2007

Method for grafting and growing a conductive organic film on a surface
patent, June 2010

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin
journal, February 2007

Screen-Printable Sol−Gel Enzyme-Containing Carbon Inks
journal, January 1996

Microneedles for drug and vaccine delivery
journal, November 2012

Packaging of electro-microfluidic devices
patent, September 2002

In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems
journal, September 2004

A Multifunctional Thin Film Au Electrode Surface Formed by Consecutive Electrochemical Reduction of Aryl Diazonium Salts
journal, March 2009