DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Shape-preserving transformations of organic matter and compositions thereof

Abstract

The present invention relates to methods of transforming organic matter into organic-inorganic composites, inorganic replicas, or conductive replicas. Organic matter, such as biological cells and tissue and organs, can be converted into such composites and replicas using the methods described herein. In particular, such methods transform organic matter (into inorganic, organic-inorganic, or conductive constructs), while simultaneously preserving microscopic and/or macroscopic structural detail.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1456910
Patent Number(s):
9989447
Application Number:
14/795,366
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08K - Use of inorganic or non-macromolecular organic substances as compounding ingredients
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jul 09
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Kaehr, Bryan J., Meyer, Kristin, and Townson, Jason L. Shape-preserving transformations of organic matter and compositions thereof. United States: N. p., 2018. Web.
Kaehr, Bryan J., Meyer, Kristin, & Townson, Jason L. Shape-preserving transformations of organic matter and compositions thereof. United States.
Kaehr, Bryan J., Meyer, Kristin, and Townson, Jason L. Tue . "Shape-preserving transformations of organic matter and compositions thereof". United States. https://www.osti.gov/servlets/purl/1456910.
@article{osti_1456910,
title = {Shape-preserving transformations of organic matter and compositions thereof},
author = {Kaehr, Bryan J. and Meyer, Kristin and Townson, Jason L.},
abstractNote = {The present invention relates to methods of transforming organic matter into organic-inorganic composites, inorganic replicas, or conductive replicas. Organic matter, such as biological cells and tissue and organs, can be converted into such composites and replicas using the methods described herein. In particular, such methods transform organic matter (into inorganic, organic-inorganic, or conductive constructs), while simultaneously preserving microscopic and/or macroscopic structural detail.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {6}
}

Works referenced in this record:

Electron microscopy of specimens in liquid
journal, October 2011


Cellular complexity captured in durable silica biocomposites
journal, October 2012


Self-Assembly of Highly Phosphorylated Silaffins and Their Function in Biosilica Morphogenesis
journal, October 2002


Superhydrophobic Aerogel That Does Not Require Per-Fluoro Compounds or Contain Any Fluorine
patent-application, February 2012


Solid-state radiation-emitting compositions and devices
patent, August 1992


Microparticles with Bimodal Nanoporosity Derived by Microemulsion Templating
journal, December 2009


Polycationic Peptides from Diatom Biosilica That Direct Silica Nanosphere Formation
journal, November 1999


Chitin-Based Organic Networks: An Integral Part of Cell Wall Biosilica in the Diatom Thalassiosira pseudonana
journal, November 2009


Molecular sieving silica membrane fabrication process
patent, June 1998


Strategies for Stabilization of Enzymes in Organic Solvents
journal, November 2013


Method for making surfactant-templated thin films
patent, May 2002


Bioinspired enzyme encapsulation for biocatalysis
journal, October 2008


Composition containing aerogel substrate loaded with tritium
patent, January 1992


Photoresponsive Release from Azobenzene-Modified Single Cubic Crystal NaCl/Silica Particles
journal, January 2011


Anisotropy of building blocks and their assembly into complex structures
journal, August 2007


Free-standing mesoporous silica films with tunable chiral nematic structures
journal, November 2010


Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
journal, June 2011


Supported inorganic membranes
patent, June 1998


Janus Particles: Synthesis, Self-Assembly, Physical Properties, and Applications
journal, March 2013


Aerosol Route to Functional Nanostructured Inorganic and Hybrid Porous Materials
journal, October 2010


Linking synchronization to self-assembly using magnetic Janus colloids
journal, November 2012


Protein-Directed Assembly of Arbitrary Three-Dimensional Nanoporous Silica Architectures
journal, January 2011


Morphology-controlled synthesis of silica nanotubes through pH- and sequence-responsive morphological change of bacterial flagellar biotemplates
journal, January 2012


Method for making surfactant-templated, high-porosity thin films
patent, August 2001


Conversion of Pollen Particles into Three-Dimensional Ceramic Replicas Tailored for Multimodal Adhesion
journal, November 2013


A Neutral Templating Route to Mesoporous Molecular Sieves
journal, February 1995


Coatings with controlled porosity and chemical properties
patent, December 1996


Cell-directed-assembly: Directing the formation of nano/bio interfaces and architectures with living cells
journal, March 2011


Interactions of bovine serum albumin and lysozyme with sodium silicate solutions
journal, June 2003


Generalized synthesis of periodic surfactant/inorganic composite materials
journal, March 1994


A Novel Method for Enzyme Immobilization: Direct Encapsulation of Acid Phosphatase in Nanoporous Silica Host Materials
journal, March 2001


Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores
journal, January 1998


Application of environmental scanning electron microscopy to determine biological surface structure
journal, February 2009


Durable polymer-aerogel based superhydrophobic coatings, a composite material
patent, March 2014


The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
journal, April 2011


Porous Nanoparticle Supported Lipid Bilayer Nanostructures
patent-application, November 2011


Prescribing diatom morphology: toward genetic engineering of biological nanomaterials
journal, December 2007


Biotemplating of Metal Carbide Microstructures: The Magnetic Leaf
journal, August 2010


New views of cells in 3D: an introduction to electron tomography
journal, January 2005


Red cell membrane: past, present, and future
journal, November 2008


Hollow sphere metal oxides
patent, June 2010


Biomimetic dual templating of silica by polysaccharide/protein assemblies
journal, August 2008


Inorganic dual-layer microporous supported membranes
patent, March 2003


Sol-gel method for encapsulating molecules
patent, December 2002


Aerosol method for nano silver-silica composite anti-microbial agent
patent, August 2012


Comparison of hexamethyldisilazane (HMDS), Peldri II, and critical-point drying methods for scanning electron microscopy of biological specimens
journal, December 1993


Scalable, Shape-Specific, Top-Down Fabrication Methods for the Synthesis of Engineered Colloidal Particles
journal, August 2010


Origins of the anomalous stress behavior in charged colloidal suspensions under shear
journal, November 2010


Bioreactor systems for the production of biopharmaceuticals from animal cells
journal, September 2006


Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
journal, November 1974


Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
journal, October 1992


Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
journal, January 2010


Evaporation-Induced Self-Assembly of Hybrid Bridged Silsesquioxane Film and Particulate Mesophases with Integral Organic Functionality
journal, June 2000


Cell-Directed Assembly of Lipid-Silica Nanostructures Providing Extended Cell Viability
journal, July 2006


Mechanical Properties of Biological Materials
book, January 2013


Luminescent light source for laser pumping and laser system containing same
patent, May 1994


Method for making surfactant-templated thin films
patent, August 2010


Cell-based composite materials with programmed structures and functions
patent, March 2016


Biocompatible Microfabrication of 3D Isolation Chambers for Targeted Confinement of Individual Cells and Their Progeny
journal, September 2012


Uncooled thin film pyroelectric IR detector with aerogel thermal isolation
patent, September 1999


Synthesis of inorganic materials with complex form
journal, July 1996


Silica replication of the hierarchical structure of wood with nanometer precision
journal, May 2011


Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles
journal, July 2010


Freeze-fracture electron microscopy
journal, March 2007


Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles
journal, February 2009


Serial Block-Face Scanning Electron Microscopy to Reconstruct Three-Dimensional Tissue Nanostructure
journal, October 2004


Bio-Inspired Materials - Mining the Old Literature for New Ideas
journal, September 2010


Mechanically Encoded Cellular Shapes for Synthesis of Anisotropic Mesoporous Particles
journal, September 2014

  • Meyer, Kristin C.; Coker, Eric N.; Bolintineanu, Dan S.
  • Journal of the American Chemical Society, Vol. 136, Issue 38, p. 13138-13141
  • https://doi.org/10.1021/ja506718z

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles
journal, June 2011


Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas
journal, December 2014


Morphological Control in Colloidal Crystal Templating of Inverse Opals, Hierarchical Structures, and Shaped Particles
journal, February 2008


Self-assembly of nanocomposite materials
patent, July 2001


Beam deceleration for block-face scanning electron microscopy of embedded biological tissue
journal, April 2012


Biphasic Janus particles with nanoscale anisotropy
journal, September 2005


Organic Templates for the Generation of Inorganic Materials
journal, March 2003


Photo-definable self-assembled materials
patent, October 2004


Diatoms, Biomineralization Processes, and Genomics
journal, November 2008


Toxicology of nanoparticles: A historical perspective
journal, January 2007


Cell-Directed Assembly of Bio/Nano Interfaces—A New Scheme for Cell Immobilization
journal, September 2007


Self-Assembled Carbon Nanotube Honeycomb Networks Using a Butterfly Wing Template as a Multifunctional Nanobiohybrid
journal, August 2013


Synthesis of microporous transition-metal-oxide molecular sieves by a supramolecular templating mechanism
journal, October 1997


Solid-state radiation-emitting compositions and devices
patent, June 1992


Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas
journal, March 2007


Jammed hard-particle packings: From Kepler to Bernal and beyond
journal, September 2010


Ultrafast holographic nanopatterning of biocatalytically formed silica
journal, September 2001


Inorganic volumetric light source excited by ultraviolet light
patent, April 1994


Biomimetics and Biotemplating of Natural Materials
journal, March 2010


Hierarchical architectures by synergy between dynamical template self-assembly and biomineralization
journal, May 2007


Molecular sieving silica membrane fabrication process
patent, August 1999


Recent bio-applications of sol–gel materials
journal, January 2006


Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
journal, June 2009


Synthesis of Macroporous Minerals with Highly Ordered Three-Dimensional Arrays of Spheroidal Voids
journal, July 1998


Template-Assisted Self-Assembly:  A Practical Route to Complex Aggregates of Monodispersed Colloids with Well-Defined Sizes, Shapes, and Structures
journal, September 2001


Encapsulation of cells within silica matrixes: Towards a new advance in the conception of living hybrid materials
journal, February 2010


Titania and Silica Materials Derived from Chemically Dehydrated Porous Botanical Templates
journal, October 2012


Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013


Diatomaceous Lessons in Nanotechnology and Advanced Materials
journal, August 2009


Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions
journal, January 1973


Modification of the physical and optical properties of the frustule of the diatom Coscinodiscus wailesii by nickel sulfate
journal, June 2007


Hydrogel microparticles from lithographic processes: Novel materials for fundamental and applied colloid science
journal, April 2011


Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
journal, September 2010


Molecular sieve sensors for selective detection at the nanogram level
patent, September 1992


The avian embryo as a model to study the development of the neural crest: a long and still ongoing story
journal, September 2004


Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials
journal, February 2010


Extensive and Intimate Association of the Cytoskeleton with Forming Silica in Diatoms: Control over Patterning on the Meso- and Micro-Scale
journal, December 2010


Fluid light guide having hydrophobic aerogel cladding layer
patent, January 2006


Molecular receptors in metal oxide sol-gel materials prepared via molecular imprinting
patent, May 2000


Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy
journal, May 2011


Red blood cell-mimicking synthetic biomaterial particles
journal, December 2009


Rho GTPases and the Actin Cytoskeleton
journal, January 1998


Prototyping of patterned functional nanostructures
patent, July 2005


Submicroscopic Structure of the Red Cell
journal, February 1948


Recent advances with anisotropic particles
journal, June 2011


Nanopatterned protein microrings from a diatom that direct silica morphogenesis
journal, February 2011


Prototyping of patterned functional nanostructures
patent, October 2002


Infiltration of Silica Inside Fibrillar Collagen
journal, October 2011


Droplet Microfluidics for Fabrication of Non-Spherical Particles
journal, November 2009


Preparation of hydrophobic coatings
patent, February 2009


Ultra-thin microporous/hybrid materials
patent, May 2012


Continuous-flow lithography for high-throughput microparticle synthesis
journal, April 2006


Assembly of large-area, highly ordered, crack-free inverse opal films
journal, May 2010


A Basis of Echinocytosis and Stomatocytosis in the Disc–Sphere Transformations of the Erythrocyte
journal, February 1999


Cell-Directed Integration into Three-Dimensional Lipid−Silica Nanostructured Matrices
journal, September 2010


Understanding enzyme immobilisation
journal, January 2009


Synthesis of Hexagonally Packed Mesoporous TiO2 by a Modified Sol–Gel Method
journal, October 1995


Preparation and Physisorption Characterization of d-Glucose-Templated Mesoporous Silica Sol−Gel Materials
journal, August 1999


An inorganic–organic proton exchange membrane for fuel cells with a controlled nanoscale pore structure
journal, February 2010


Background, status and future of the Transmission Electron Aberration-corrected Microscope project
journal, August 2009

  • Dahmen, U.; Erni, R.; Radmilovic, V.
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 367, Issue 1903, p. 3795-3808
  • https://doi.org/10.1098/rsta.2009.0094

Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device
journal, March 2013


Geometric curvature controls the chemical patchiness and self-assembly of nanoparticles
journal, August 2013


Species-specific polyamines from diatoms control silica morphology
journal, December 2000


Nanoparticles in Medicine: Therapeutic Applications and Developments
journal, October 2007


Scale-up analysis for a CHO cell culture process in large-scale bioreactors
journal, July 2009


Structural and molecular interrogation of intact biological systems
journal, April 2013


Erythrocyte-Inspired Delivery Systems
journal, August 2012


Structure analysis of sputter-coated and ion-beam sputter-coated films: a comparative study
journal, November 1983


Mechanical characterization of liver capsule through uniaxial quasi-static tensile tests until failure
journal, August 2010


Drying cells for SEM, AFM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells
journal, April 1997


Squishy Non-Spherical Hydrogel Microparticles
journal, September 2009


Aerosol-assisted self-assembly of mesostructured spherical nanoparticles
journal, March 1999


Method for net-shaping using aerogels
patent, July 2001


Self-assembly of water-soluble nanocrystals
patent, January 2012


Preparation of high porosity xerogels by chemical surface modification.
patent, October 1996


Method of Making Dense, Conformal, Ultra-Thin Cap Layers for Nanoporous Low-K ILD by Plasma Assisted Atomic Layer Deposition
patent-application, August 2011


A new family of mesoporous molecular sieves prepared with liquid crystal templates
journal, December 1992


Coatings with controlled porosity and chemical properties
patent, July 1993


Protein- and Peptide-Directed Syntheses of Inorganic Materials
journal, November 2008


Recent developments in dynamic transmission electron microscopy
journal, February 2012


Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors
journal, June 1998


Process for making solid-state radiation-emitting composition
patent, August 1993


Aerosol-assisted synthesis of monodisperse single-crystalline α-cristobalite nanospheres
journal, January 2012


Process to form mesostructured films
patent, January 1999


Prospects of Manipulating Diatom Silica Nanostructure
journal, January 2005


Proteins in Mesoporous Silicates
journal, October 2008


Tobacco mosaic virus templated synthesis of one dimensional inorganic–polymer hybrid fibres
journal, January 2009


Decellularization of tissues and organs
journal, March 2006


Stomatocyte-discocyte-echinocyte sequence of the human red blood cell: Evidence for the bilayer- couple hypothesis from membrane mechanics
journal, December 2002


Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles
journal, January 2011


Photo-definable self-assembled materials
patent, February 2008


DNA translocation through an array of kinked nanopores
journal, August 2010


Application of AFM in understanding biomineral formation in diatoms
journal, December 2007


Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro
journal, January 1999