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Title: Targeted self-assembly of functionalized carbon nanotubes on tumors

Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1452898
Assignee:
Scheinberg, David A. CHO
Patent Number(s):
9,976,137
Application Number:
14/318,112
Contract Number:
SC0002456
Resource Relation:
Patent File Date: 2014 Jun 27
Research Org:
Memorial Sloan Kettering Cancer Center, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES