Targeted self-assembly of functionalized carbon nanotubes on tumors
Abstract
Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.
- Inventors:
- Issue Date:
- Research Org.:
- Memorial Sloan Kettering Cancer Center, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1452898
- Patent Number(s):
- 9976137
- Application Number:
- 14/318,112
- Assignee:
- Scheinberg, David A.
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- SC0002456
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Jun 27
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., and Mulvey, J. Justin. Targeted self-assembly of functionalized carbon nanotubes on tumors. United States: N. p., 2018.
Web.
Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., & Mulvey, J. Justin. Targeted self-assembly of functionalized carbon nanotubes on tumors. United States.
Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., and Mulvey, J. Justin. Tue .
"Targeted self-assembly of functionalized carbon nanotubes on tumors". United States. https://www.osti.gov/servlets/purl/1452898.
@article{osti_1452898,
title = {Targeted self-assembly of functionalized carbon nanotubes on tumors},
author = {Scheinberg, David A. and McDevitt, Michael R. and Villa, Carlos H. and Mulvey, J. Justin},
abstractNote = {Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {5}
}
Works referenced in this record:
Single wall nanotube constructs and uses therefor
patent, September 2013
- Scheinberg, David A.; McDevitt, Michael R.; Antczak, Christophe
- US Patent Document 8,540,965
Antisense and pretargeting optical imaging
patent-application, June 2011
- Hnatowich, Don; Nakamura, Kayoko; Wang, Yi
- US Patent Document 12/009452; 20110158913
Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes
journal, December 2008
- Villa, Carlos H.; McDevitt, Michael R.; Escorcia, Freddy E.
- Nano Letters, Vol. 8, Issue 12, p. 4221-4228