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Title: Noise reduction methods for nucleic acid and macromolecule sequencing

Methods, systems, and devices are disclosed for processing macromolecule sequencing data with substantial noise reduction. In one aspect, a method for reducing noise in a sequential measurement of a macromolecule comprising serial subunits includes cross-correlating multiple measured signals of a physical property of subunits of interest of the macromolecule, the multiple measured signals including the time data associated with the measurement of the signal, to remove or at least reduce signal noise that is not in the same frequency and in phase with the systematic signal contribution of the measured signals.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1440025
Assignee:
The Regents of the University of California (Oakland, CA); Los Alamos National Laboratory (Los Alamos, NM) LANL
Patent Number(s):
9,965,586
Application Number:
14/664,738
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2015 Mar 20
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English