Brain-specific enhancers for cell-based therapy
Abstract
Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.
- Inventors:
-
- (Jasmine)
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1436498
- Patent Number(s):
- 9952216
- Application Number:
- 14/512,306
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Oct 10
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, and Kriegstein, Arnold. Brain-specific enhancers for cell-based therapy. United States: N. p., 2018.
Web.
Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, & Kriegstein, Arnold. Brain-specific enhancers for cell-based therapy. United States.
Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, and Kriegstein, Arnold. Tue .
"Brain-specific enhancers for cell-based therapy". United States. https://www.osti.gov/servlets/purl/1436498.
@article{osti_1436498,
title = {Brain-specific enhancers for cell-based therapy},
author = {Visel, Axel and Rubenstein, John L.R. and Chen, Ying-Jiun and Pennacchio, Len A. and Vogt, Daniel and Nicholas, Cory and Kriegstein, Arnold},
abstractNote = {Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}
}
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