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Title: Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control


Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.

Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2015 Dec 08
Country of Publication:
United States

Citation Formats

Cary, Robert B. Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control. United States: N. p., 2018. Web.
Cary, Robert B. Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control. United States.
Cary, Robert B. Tue . "Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control". United States.
title = {Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control},
author = {Cary, Robert B.},
abstractNote = {Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}

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