Title: Materials and methods for preventing and treating anastomotic leaks

Abstract

Materials and methods for preventing and treating anastomotic leaks are disclosed. Data establishes that pathogenic microbes interfere with establishing epithelial cell barriers in anastomoses and, more generally, with the reconnection of any two portions of like or different tissues comprising epithelia. Suitable prophylactic and therapeutic composition comprise, e.g., a phosphorylated high molecular weight polyethylene glycol compound.

Inventors:

Alverdy, John C.

Issue Date:

2018-04-10

Research Org.:

Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1434709

Patent Number(s):

9937199

Application Number:

14/421,762

Assignee:

THE UNIVERSITY OF CHICAGO (Chicago, IL)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B17/11 - for performing anastomosis

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/66 - Phosphorus compounds
A61K31/765 - Polymers containing oxygen
A61K31/77 - of oxiranes
A61K33/42 - Phosphorus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

A61L2300/112 - Phosphorus-containing compounds, e.g. phosphates, phosphonates
A61L31/028 - {Other inorganic materials not covered by A61L31/022 - A61L31/026}
A61L31/06 - obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {
A61L31/16 - Biologically active materials, e.g. therapeutic substances {

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

C08L71/02 - Polyalkylene oxides

Show less

DOE Contract Number:  

AC02-06CH11357

Resource Type:

Patent

Resource Relation:

Patent File Date: 2013 Mar 14

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES