Title: Mutations in iron-sulfur cluster proteins that improve xylose utilization

Abstract

There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Inventors:

Froehlich, Allan; Henningsen, Brooks; Covalla, Sean; Zelle, Rintze M.

Issue Date:

2018-03-20

Research Org.:

Lallemand Hungary Liquidity Management LLC, Budapest, HU (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1429846

Patent Number(s):

9920312

Application Number:

14/821,955

Assignee:

Lallemand Hungary Liquidity Management LLC (Budapest, HU)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/395 - from Saccharomyces

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/92 - Glucose isomerase {

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/06 - Ethanol, i.e. non-beverage

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y503/01005 - Xylose isomerase

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

Y02E50/10 - Biofuels

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DOE Contract Number:  

FC36-08GO18103; PS02-06ER64304

Resource Type:

Patent

Resource Relation:

Patent File Date: 2015 Aug 10

Country of Publication:

Hungary

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES