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Title: Mutations in iron-sulfur cluster proteins that improve xylose utilization

Abstract

There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lallemand Hungary Liquidity Management LLC, Budapest, HU (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1429846
Patent Number(s):
9920312
Application Number:
14/821,955
Assignee:
Lallemand Hungary Liquidity Management LLC (Budapest, HU)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FC36-08GO18103; PS02-06ER64304
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Aug 10
Country of Publication:
Hungary
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary: N. p., 2018. Web.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, & Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Tue . "Mutations in iron-sulfur cluster proteins that improve xylose utilization". Hungary. https://www.osti.gov/servlets/purl/1429846.
@article{osti_1429846,
title = {Mutations in iron-sulfur cluster proteins that improve xylose utilization},
author = {Froehlich, Allan and Henningsen, Brooks and Covalla, Sean and Zelle, Rintze M.},
abstractNote = {There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {Hungary},
year = {2018},
month = {3}
}

Works referenced in this record:

Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast
journal, December 2007


Isolation of xylose isomerases by sequence- and function-based screening from a soil metagenomic library
journal, January 2011


Molecular and industrial aspects of glucose isomerase.
journal, January 1996


The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications
journal, January 1987


The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of Xy1A enzymes
journal, April 1994


Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability
journal, May 1999


Codon usage tabulated from international DNA sequence databases: status for the year 2000
journal, January 2000


Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details
journal, December 2013


Localization of the essential histidine and carboxylate group in d-xylose isomerases
journal, February 1990


Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis
journal, February 2008


Methods for the Improvement of Product Yield and Production in a Microorganism Through the Addition of Alternate Electron Acceptors
patent-application, July 2014


Recombinant Yeast Having Enhanced Xylose Fermentation Capabilities and Methods of Use
patent-application, October 2015


Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2
journal, March 2014


An efficient xylose-fermenting recombinant Saccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile
journal, October 2012


Engineering acidic Streptomyces rubiginosus D-xylose isomerase by rational enzyme design
journal, January 2014


Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation
journal, February 2005