Mutations in iron-sulfur cluster proteins that improve xylose utilization
Abstract
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
- Inventors:
- Issue Date:
- Research Org.:
- Lallemand Hungary Liquidity Management LLC, Budapest, HU (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1429846
- Patent Number(s):
- 9920312
- Application Number:
- 14/821,955
- Assignee:
- Lallemand Hungary Liquidity Management LLC (Budapest, HU)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FC36-08GO18103; PS02-06ER64304
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Aug 10
- Country of Publication:
- Hungary
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary: N. p., 2018.
Web.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, & Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Tue .
"Mutations in iron-sulfur cluster proteins that improve xylose utilization". Hungary. https://www.osti.gov/servlets/purl/1429846.
@article{osti_1429846,
title = {Mutations in iron-sulfur cluster proteins that improve xylose utilization},
author = {Froehlich, Allan and Henningsen, Brooks and Covalla, Sean and Zelle, Rintze M.},
abstractNote = {There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {Hungary},
year = {2018},
month = {3}
}
Works referenced in this record:
Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast
journal, December 2007
- Li, L.; Bagley, D.; Ward, D. M.
- Molecular and Cellular Biology, Vol. 28, Issue 4, p. 1326-1337
Isolation of xylose isomerases by sequence- and function-based screening from a soil metagenomic library
journal, January 2011
- Parachin, Nádia; Gorwa-Grauslund, Marie F.
- Biotechnology for Biofuels, Vol. 4, Article No. 9
Molecular and industrial aspects of glucose isomerase.
journal, January 1996
- Bhosale, S. H.; Rao, M. B.; Deshpande, V. V.
- Microbiological reviews, Vol. 60, Issue 2
The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications
journal, January 1987
- Sharp, Paul M.; Li, Wen-Hsiung
- Nucleic Acids Research, Vol. 15, Issue 3, p. 1281-1295
The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of Xy1A enzymes
journal, April 1994
- Meaden, Philip G.; Aduse-Opoku, Joseph; Reizer, Jonathan
- Gene, Vol. 141, Issue 1, p. 97-101
Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability
journal, May 1999
- Chang, Changsoo; Park, Byung Chul; Lee, Dae-Sil
- Journal of Molecular Biology, Vol. 288, Issue 4, p. 623-634
Codon usage tabulated from international DNA sequence databases: status for the year 2000
journal, January 2000
- Nakamura, Yasukazu; Gojobori, Takashi; Ikemura, Toshimichi
- Nucleic Acids Research, Vol. 28, Issue 1, p. 292-292
Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae
journal, November 2012
- Zhou, Hang; Cheng, Jing-sheng; Wang, Benjamin L.
- Metabolic Engineering, Vol. 14, Issue 6, p. 611-622
Structures of d-xylose isomerase from Arthrobacter strain B3728 containing the inhibitors xylitol and d-sorbitol at 2.5 Å and 2.3 Å resolution, respectively
journal, July 1989
- Henrick, K.; Collyer, C. A.; Blow, D. M.
- Journal of Molecular Biology, Vol. 208, Issue 1, p. 129-157
Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details
journal, December 2013
- Outten, Caryn E.; Albetel, Angela-Nadia
- Current Opinion in Microbiology, Vol. 16, Issue 6, p. 662-668
Localization of the essential histidine and carboxylate group in d-xylose isomerases
journal, February 1990
- Vangrysperre, W.; Van Damme, J.; Vandekerckhove, J.
- Biochemical Journal, Vol. 265, Issue 3, p. 699-705
Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis
journal, February 2008
- Kumánovics, Attila; Chen, Opal S.; Li, Liangtao
- Journal of Biological Chemistry, Vol. 283, Issue 16, p. 10276-10286
Methods for the Improvement of Product Yield and Production in a Microorganism Through the Addition of Alternate Electron Acceptors
patent-application, July 2014
- Argyros, Aaron; Sillers, William Ryan; Barrett, Trisha
- US Patent Application 14/110075; 20140186930
Recombinant Yeast Having Enhanced Xylose Fermentation Capabilities and Methods of Use
patent-application, October 2015
- Sato, Trey Kyle; Piotrowski, Jeff Scott
- US Patent Application 14/683724; 20150307872
Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2
journal, March 2014
- Poor, C. B.; Wegner, S. V.; Li, H.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 11, p. 4043-4048
An efficient xylose-fermenting recombinant Saccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile
journal, October 2012
- Shen, Yu; Chen, Xiao; Peng, Bingyin
- Applied Microbiology and Biotechnology, Vol. 96, Issue 4, p. 1079-1091
Engineering acidic Streptomyces rubiginosus D-xylose isomerase by rational enzyme design
journal, January 2014
- Waltman, M. J.; Yang, Z. K.; Langan, P.
- Protein Engineering Design and Selection, Vol. 27, Issue 2, p. 59-64
Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation
journal, February 2005
- Kuyper, Marko; Hartog, Miranda; Toirkens, Maurice
- FEMS Yeast Research, Vol. 5, Issue 4-5, p. 399-409