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Title: Biological production of organic compounds

Abstract

Methods of producing ethylene oxide and ethylene glycol are disclosed herein. Ethylene produced by cyanobacteria engineered to express ethylene-forming enzymes may be converted to ethylene oxide by bacteria engineered to express a monooxygenase enzyme. Ethylene oxide may be converted to ethylene glycol by exposure to an acidic solution. The methods may be performed in a bioreactor.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1426794
Patent Number(s):
9914947
Application Number:
15/054,868
Assignee:
Alliance for Sustainable Energy, LLC (Golden, CO)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AC36-08GO28308
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Feb 26
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Yu, Jianping, Wang, Bo, Paddock, Troy, Carrieri, Damian, Maness, Pin-Ching, and Seibert, Michael. Biological production of organic compounds. United States: N. p., 2018. Web.
Yu, Jianping, Wang, Bo, Paddock, Troy, Carrieri, Damian, Maness, Pin-Ching, & Seibert, Michael. Biological production of organic compounds. United States.
Yu, Jianping, Wang, Bo, Paddock, Troy, Carrieri, Damian, Maness, Pin-Ching, and Seibert, Michael. Tue . "Biological production of organic compounds". United States. https://www.osti.gov/servlets/purl/1426794.
@article{osti_1426794,
title = {Biological production of organic compounds},
author = {Yu, Jianping and Wang, Bo and Paddock, Troy and Carrieri, Damian and Maness, Pin-Ching and Seibert, Michael},
abstractNote = {Methods of producing ethylene oxide and ethylene glycol are disclosed herein. Ethylene produced by cyanobacteria engineered to express ethylene-forming enzymes may be converted to ethylene oxide by bacteria engineered to express a monooxygenase enzyme. Ethylene oxide may be converted to ethylene glycol by exposure to an acidic solution. The methods may be performed in a bioreactor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {3}
}

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Works referenced in this record:

Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase
journal, January 2015


Photo-catalytic conversion of carbon dioxide to organic acids by a recombinant cyanobacterium incapable of glycogen storage
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Glycogen content and nitrogenase activity in Anabaena variabilis
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Heterologous expression of the gene for the ethylene-forming enzyme from Pseudomonas syringae in the cyanobacterium Synechococcus
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Changes in photosynthesis and pigmentation in an agp deletion mutant of the cyanobacterium Synechocystis sp.
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Sucrose accumulation in salt-stressed cells of agp gene deletion-mutant in cyanobacterium Synechocystis sp. PCC 6803
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Carbohydrate Metabolism in Mutants of the Cyanobacterium Synechococcus elongatus PCC 7942 Defective in Glycogen Synthesis
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Construction and analysis of a recombinant cyanobacterium expressing a chromosomally inserted gene for an ethylene-forming enzyme at the psbAI locus
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Sustained photosynthetic conversion of CO2 to ethylene in recombinant cyanobacterium Synechocystis 6803
journal, January 2012


Modification of carbon partitioning to enhance PHB production in Synechocystis sp. PCC6803
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Phosphoketolase pathway contributes to carbon metabolism in cyanobacteria
journal, December 2015