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Title: Growth arrested cells useful for producing compounds

Abstract

The present invention provides for a genetically modified host cell in a growth-arrested state producing an antibiotic.

Inventors:
;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1423449
Patent Number(s):
9902964
Application Number:
14/709,328
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 May 11
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Bokinsky, Gregory E., and Keasling, Jay D.. Growth arrested cells useful for producing compounds. United States: N. p., 2018. Web.
Bokinsky, Gregory E., & Keasling, Jay D.. Growth arrested cells useful for producing compounds. United States.
Bokinsky, Gregory E., and Keasling, Jay D.. Tue . "Growth arrested cells useful for producing compounds". United States. https://www.osti.gov/servlets/purl/1423449.
@article{osti_1423449,
title = {Growth arrested cells useful for producing compounds},
author = {Bokinsky, Gregory E. and Keasling, Jay D.},
abstractNote = {The present invention provides for a genetically modified host cell in a growth-arrested state producing an antibiotic.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {2}
}

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Works referenced in this record:

Bacterial persistence by RNA endonucleases
journal, July 2011


The Stringent Response and Cell Cycle Arrest in Escherichia coli
journal, December 2008


Kinase Activity of Overexpressed HipA Is Required for Growth Arrest and Multidrug Tolerance in Escherichia coli
journal, October 2006


Persister Cells
journal, October 2010


ppGpp is the major source of growth rate control in E. coli
journal, October 2010


Direct binding targets of the stringent response alarmone (p)ppGpp
journal, August 2012


HipA-Triggered Growth Arrest and β-Lactam Tolerance in Escherichia coli Are Mediated by RelA-Dependent ppGpp Synthesis
journal, May 2013


Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB
journal, January 2009


Regulation of growth and death in Escherichia coli by toxin–antitoxin systems
journal, September 2011


ppGpp inhibits the activity of Escherichia coli DnaG primase
journal, January 2010


Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli
journal, January 2013


Nutritional Control of Elongation of DNA Replication by (p)ppGpp
journal, March 2007


DksA Affects ppGpp Induction of RpoS at a Translational Level
journal, August 2002


Persister cells and tolerance to antimicrobials
journal, January 2004


Increased Persistence in Escherichia coli Caused by Controlled Expression of Toxins or Other Unrelated Proteins
journal, May 2006


Delayed-relaxed response explained by hyperactivation of RelE
journal, June 2004


Manipulation of the carbon storage regulator system for metabolite remodeling and biofuel production in Escherichia coli
journal, January 2012


Phosphorylation of Elongation Factor Tu Prevents Ternary Complex Formation
journal, June 1995


A comprehensive library of fluorescent transcriptional reporters for Escherichia coli
journal, August 2006


Heterogeneous bacterial persisters and engineering approaches to eliminate them
journal, October 2011


Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria
journal, November 2011


Bacterial Persistence and Toxin-Antitoxin Loci
journal, October 2012


Bacterial Persistence as a Phenotypic Switch
journal, September 2004