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Title: Chimeric OspA genes, proteins and methods of use thereof

The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
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Issue Date:
OSTI Identifier:
Brookhaven Science Associates, LLC (Upton, NY) BNL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2016 Feb 22
Research Org:
Research Foundation of the State University of New York, Amherst, NY; Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Basic local alignment search tool
journal, October 1990
  • Altschul, Stephen F.; Gish, Warren; Miller, Webb
  • Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410
  • DOI: 10.1016/S0022-2836(05)80360-2

Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor
journal, August 2000
  • Frankel, Arthur E.; Ramage, Jason; Kiser, Melanie
  • Protein Engineering, Design and Selection, Vol. 13, Issue 8, p. 575-581
  • DOI: 10.1093/protein/13.8.575

A new technique for the assay of infectivity of human adenovirus 5 DNA
journal, April 1973

Amino acid substitution matrices from protein blocks.
journal, November 1992
  • Henikoff, S.; Henikoff, J. G.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 22, p. 10915-10919
  • DOI: 10.1073/pnas.89.22.10915

Applications and statistics for multiple high-scoring segments in molecular sequences.
journal, June 1993
  • Karlin, S.; Altschul, S. F.
  • Proceedings of the National Academy of Sciences, Vol. 90, Issue 12, p. 5873-5877
  • DOI: 10.1073/pnas.90.12.5873

Continuous cultures of fused cells secreting antibody of predefined specificity
journal, August 1975
  • K√∂hler, G.; Milstein, C.
  • Nature, Vol. 256, Issue 5517, p. 495-497
  • DOI: 10.1038/256495a0

By-passing immunization: Human antibodies from V-gene libraries displayed on phage
journal, December 1991
  • Marks, James D.; Hoogenboom, Hennie R.; Bonnert, Timothy P.
  • Journal of Molecular Biology, Vol. 222, Issue 3, p. 581-597
  • DOI: 10.1016/0022-2836(91)90498-U

Improved tools for biological sequence comparison.
journal, April 1988
  • Pearson, W. R.; Lipman, D. J.
  • Proceedings of the National Academy of Sciences, Vol. 85, Issue 8, p. 2444-2448
  • DOI: 10.1073/pnas.85.8.2444

Comparison of biosequences
journal, December 1981

From genes to protein structure and function: novel applications of computational approaches in the genomic era
journal, January 2000