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Title: Selective high-affinity polydentate ligands and methods of making such

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1419794
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA) LLNL
Patent Number(s):
9,884,070
Application Number:
12/988,801
Contract Number:
AC52-07NA27344
Resource Relation:
Patent File Date: 2009 Apr 21
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Works referenced in this record:

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Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors
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Lead discovery using molecular docking
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  • Shoichet, Brian K.; McGovern, Susan L.; Wei, Binqing
  • Current Opinion in Chemical Biology, Vol. 6, Issue 4, p. 439-446
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