Title: Methods and compositions for protection of cells and tissues from computed tomography radiation

Abstract

Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.

Inventors:

Grdina, David J.

Issue Date:

Tue Jan 30 00:00:00 EST 2018

Research Org.:

The University of Chicago, Chicago, IL (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1418996

Patent Number(s):

9877976

Application Number:

13/822,223

Assignee:

The University of Chicago (Chicago, IL)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B6/032 - {Transmission computed tomography [CT]}
A61B6/508 - {for non-human patients}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/132 - having two or more amino groups, e.g. spermidine, putrescine
A61K31/145 - having sulfur, e.g. thiurams
A61K31/355 - Tocopherols, e.g. vitamin E
A61K31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
A61K33/04 - Sulfur, selenium or tellurium
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K49/0008 - {Screening agents using

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P39/06 - Free radical scavengers or antioxidants

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DOE Contract Number:  

FG02-05ER64086

Resource Type:

Patent

Resource Relation:

Patent File Date: 2011 Sep 16

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES