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Title: Methods and compositions for protection of cells and tissues from computed tomography radiation

Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.
Inventors:
Issue Date:
OSTI Identifier:
1418996
Assignee:
The University of Chicago (Chicago, IL) CHO
Patent Number(s):
9,877,976
Application Number:
13/822,223
Contract Number:
FG02-05ER64086
Resource Relation:
Patent File Date: 2011 Sep 16
Research Org:
The University of Chicago, Chicago, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability
journal, December 2008

Potential Utility of Radioprotective Agents in the Practice of Nuclear Medicine
journal, December 2009
  • Hosseinimehr, Seyed Jalal
  • Cancer Biotherapy & Radiopharmaceuticals, Vol. 24, Issue 6, p. 723-731
  • DOI: 10.1089/cbr.2009.0635

Computed tomographic assessment of radiation induced damage in the lung of normal and WR 2721 protected LAF1 mice
journal, November 1986
  • Miller, G. G.; Dawson, D. T.; Battista, J. J.
  • International Journal of Radiation Oncology*Biology*Physics, Vol. 12, Issue 11, p. 1971-1975
  • DOI: 10.1016/0360-3016(86)90134-3

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