skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Engineered microbes and methods for microbial oil overproduction from cellulosic materials

Abstract

The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.

Inventors:
;
Issue Date:
Research Org.:
Massachusetts Institute of Technology, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1418983
Patent Number(s):
9,879,248
Application Number:
14/817,489
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
DOE Contract Number:  
AR0000059
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Aug 04
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Stephanopoulos, Gregory, and Tai, Mitchell. Engineered microbes and methods for microbial oil overproduction from cellulosic materials. United States: N. p., 2018. Web.
Stephanopoulos, Gregory, & Tai, Mitchell. Engineered microbes and methods for microbial oil overproduction from cellulosic materials. United States.
Stephanopoulos, Gregory, and Tai, Mitchell. Tue . "Engineered microbes and methods for microbial oil overproduction from cellulosic materials". United States. https://www.osti.gov/servlets/purl/1418983.
@article{osti_1418983,
title = {Engineered microbes and methods for microbial oil overproduction from cellulosic materials},
author = {Stephanopoulos, Gregory and Tai, Mitchell},
abstractNote = {The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Physiology and genetics of the dimorphic fungus Yarrowia lipolytica
journal, April 1997


Yarrowia lipolytica as a model for bio-oil production
journal, November 2009

  • Beopoulos, Athanasios; Cescut, Julien; Haddouche, Ramdane
  • Progress in Lipid Research, Vol. 48, Issue 6, p. 375-387
  • DOI: 10.1016/j.plipres.2009.08.005

Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts
journal, April 2005


The Crabtree Effect and its Relation to the Petite Mutation
journal, August 1966


Induction of xylulose-5-phosphate phosphoketolase in a variety of yeasts grown ond-xylose: the key to efficient xylose metabolism
journal, September 1984

  • Evans, Christopher Thomas; Ratledge, Colin
  • Archives of Microbiology, Vol. 139, Issue 1, p. 48-52
  • DOI: 10.1007/BF00692711

Yarrowia lipolytica Mutants Devoid of Pyruvate Carboxylase Activity Show an Unusual Growth Phenotype
journal, February 2005


Selection of Direct Transesterification as the Preferred Method for Assay of Fatty Acid Content of Microalgae
journal, September 2010

  • Griffiths, M. J.; van Hille, R. P.; Harrison, S. T. L.
  • Lipids, Vol. 45, Issue 11, p. 1053-1060
  • DOI: 10.1007/s11745-010-3468-2

Engineering yeasts for xylose metabolism
journal, June 2006


Saccharomyces cerevisiae Engineered for Xylose Metabolism Exhibits a Respiratory Response
journal, November 2004


Toward More Efficient Protein Expression: Keep the Message Simple
journal, January 2006

  • Kalwy, Stephan; Rance, James; Young, Robert
  • Molecular Biotechnology, Vol. 34, Issue 2, p. 151-156
  • DOI: 10.1385/MB:34:2:151

DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Δsnf2 disruptant of Saccharomyces cerevisiae
journal, November 2007

  • Kamisaka, Yasushi; Tomita, Nao; Kimura, Kazuyoshi
  • Biochemical Journal, Vol. 408, Issue 1, p. 61-68
  • DOI: 10.1042/BJ20070449

Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae
journal, January 2007

  • Karhumaa, Kaisa; Sanchez, Rosa; Hahn-Hagerdal, Bärbel
  • Microbial Cell Factories, Vol. 6, Issue 1, 5 p.
  • DOI: 10.1186/1475-2859-6-5

Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle
journal, March 2004


Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives
journal, July 2009

  • Matsushika, Akinori; Inoue, Hiroyuki; Kodaki, Tsutomu
  • Applied Microbiology and Biotechnology, Vol. 84, Issue 1, p. 37-53
  • DOI: 10.1007/s00253-009-2101-x

Accumulation of a Cocoa-Butter-Like Lipid by Yarrowia lipolytica Cultivated on Agro-Industrial Residues
journal, February 2003

  • Papanikolaou, Seraphim; Muniglia, Lionel; Chevalot, Isabelle
  • Current Microbiology, Vol. 46, Issue 2, p. 124-130
  • DOI: 10.1007/s00284-002-3833-3

Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture
journal, March 2002


Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures
journal, March 2002

  • Papanikolaou, S.; Chevalot, I.; Komaitis, M.
  • Applied Microbiology and Biotechnology, Vol. 58, Issue 3, p. 308-312
  • DOI: 10.1007/s00253-001-0897-0

Different effectors of dimorphism in Yarrowia lipolytica
journal, December 2002

  • Ruiz-Herrera, José; Sentandreu, Rafael
  • Archives of Microbiology, Vol. 178, Issue 6, p. 477-483
  • DOI: 10.1007/s00203-002-0478-3

Transcription Analysis of Recombinant Saccharomyces cerevisiae Reveals Novel Responses to Xylose
journal, January 2006

  • Salusjärvi, Laura; Pitkänen, Juha-Pekka; Aristidou, Aristos
  • Applied Biochemistry and Biotechnology, Vol. 128, Issue 3, p. 237-274
  • DOI: 10.1385/ABAB:128:3:237

The use of Yarrowia lipolytica to reduce pollution in olive mill wastewaters
journal, October 1997


Screening of yeasts for growth on crude glycerol and optimization of biomass production
journal, April 2012


Adaptation of the xylose fermenting yeast Saccharomyces cerevisiae F12 for improving ethanol production in different fed-batch SSF processes
journal, June 2010

  • Tomás-Pejó, E.; Ballesteros, M.; Oliva, J. M.
  • Journal of Industrial Microbiology & Biotechnology, Vol. 37, Issue 11, p. 1211-1220
  • DOI: 10.1007/s10295-010-0768-8

Lipid production from Yarrowia lipolytica Po1g grown in sugarcane bagasse hydrolysate
journal, October 2011

  • Tsigie, Yeshitila Asteraye; Wang, Chun-Yuan; Truong, Chi-Thanh
  • Bioresource Technology, Vol. 102, Issue 19, p. 9216-9222
  • DOI: 10.1016/j.biortech.2011.06.047

A molecular transporter engineering approach to improving xylose catabolism in Saccharomyces cerevisiae
journal, July 2012


Comprehensive Algorithm for Quantitative Real-Time Polymerase Chain Reaction
journal, October 2005

  • Zhao, Sheng; Fernald, Russell D.
  • Journal of Computational Biology, Vol. 12, Issue 8, p. 1047-1064
  • DOI: 10.1089/cmb.2005.12.1047