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Title: Filtration device for rapid separation of biological particles from complex matrices

Abstract

Methods and systems for filtering of biological particles are disclosed. Filtering membranes separate adjacent chambers. Through osmotic or electrokinetic processes, flow of particles is carried out through the filtering membranes. Cells, viruses and cell waste can be filtered depending on the size of the pores of the membrane. A polymer brush can be applied to a surface of the membrane to enhance filtering and prevent fouling.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1416743
Patent Number(s):
9861939
Application Number:
14/874,326
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Oct 02
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION

Citation Formats

Kim, Sangil, Naraghi-Arani, Pejman, and Liou, Megan. Filtration device for rapid separation of biological particles from complex matrices. United States: N. p., 2018. Web.
Kim, Sangil, Naraghi-Arani, Pejman, & Liou, Megan. Filtration device for rapid separation of biological particles from complex matrices. United States.
Kim, Sangil, Naraghi-Arani, Pejman, and Liou, Megan. Tue . "Filtration device for rapid separation of biological particles from complex matrices". United States. https://www.osti.gov/servlets/purl/1416743.
@article{osti_1416743,
title = {Filtration device for rapid separation of biological particles from complex matrices},
author = {Kim, Sangil and Naraghi-Arani, Pejman and Liou, Megan},
abstractNote = {Methods and systems for filtering of biological particles are disclosed. Filtering membranes separate adjacent chambers. Through osmotic or electrokinetic processes, flow of particles is carried out through the filtering membranes. Cells, viruses and cell waste can be filtered depending on the size of the pores of the membrane. A polymer brush can be applied to a surface of the membrane to enhance filtering and prevent fouling.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 09 00:00:00 EST 2018},
month = {Tue Jan 09 00:00:00 EST 2018}
}

Works referenced in this record:

Virus-removing bag and virus-removing method using the same
patent-application, March 2006


Magnetically Responsive Membranes
patent-application, August 2014


Biocompatible hydrogel polymer matrix for delivery of cells
patent-application, September 2014


Capture and alignment of phi29 viral particles in sub-40 nanometer porous alumina membranes
journal, September 2008


Continuous dielectrophoretic bacterial separation and concentration from physiological media of high conductivity
journal, January 2011


Rapid detection of bacterial cell from whole blood: Integration of DNA sample preparation into single micro-PCR chip
journal, May 2011


Development of a virus concentration method using lanthanum-based chemical flocculation coupled with modified membrane filtration procedures
journal, June 2013