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Title: Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells

In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
Inventors:
;
Issue Date:
OSTI Identifier:
1415623
Assignee:
STC. UNM (Albuquerque, NM); National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL-A
Patent Number(s):
9,855,217
Application Number:
15/023,110
Contract Number:
AC04-94AL85000
Resource Relation:
Patent File Date: 2014 Sep 18
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013

Control of the morphology of nanostructured particles prepared by the spray drying of a nanoparticle sol
journal, September 2003
  • Iskandar, Ferry; Gradon, Leon; Okuyama, Kikuo
  • Journal of Colloid and Interface Science, Vol. 265, Issue 2, p. 296-303
  • DOI: 10.1016/S0021-9797(03)00519-8