Producing alpha-olefins using polyketide synthases
Abstract
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1415467
- Patent Number(s):
- 9,856,461
- Application Number:
- 14/853,821
- Assignee:
- The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Sep 14
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., and Keasling, Jay D. Producing alpha-olefins using polyketide synthases. United States: N. p., 2018.
Web.
Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., & Keasling, Jay D. Producing alpha-olefins using polyketide synthases. United States.
Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., and Keasling, Jay D. Tue .
"Producing alpha-olefins using polyketide synthases". United States. https://www.osti.gov/servlets/purl/1415467.
@article{osti_1415467,
title = {Producing alpha-olefins using polyketide synthases},
author = {Fortman, Jeffrey L. and Katz, Leonard and Steen, Eric J. and Keasling, Jay D.},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {1}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
patent, May 2003
- Khosla, Chaitan; Kao, Camilla
- US Patent Document 6,558,942
Production of Polyketides
patent-application, December 2007
- Arslanian, Robert L.
- US Patent Application 11/200525; 20070281343
3-Hydroxypropionic Acid And Other Organic Compounds
patent-application, March 2008
- Gokarn, Ravi R.; Selfifonova, Olga V.; Jessen, Holly Jean
- US Patent Application 11/942669; 20080076167
Production of Polyketides
patent-application, April 2009
- Julien, Bryan; Katz, Leonard; Khosla, Chaitan
- US Patent Application 11/933002; 20090111151
Biosynthesis Of 1-Alkenes In Engineered Microorganisms
patent-application, December 2010
- Ridley, Christian Perry; Reppas, Nikos Basil
- US Patent Application 12/821107; 20100330642
Method For Enzymatic Production Of Decarboxylated Polyketides And Fatty Acids
patent-application, April 2011
- Sherman, David H.; Smith, Janet L.; Gu, Liangcai
- US Patent Application 12/842549; 20110091952
Propionyl-Coenzyme A Synthase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation
journal, January 2002
- Alber, Birgit E.; Fuchs, Georg
- Journal of Biological Chemistry, Vol. 277, Issue 14, p. 12137-12143
Engineering of modular polyketide synthases to produce novel polyketides
journal, August 1998
- Carreras, Christopher W.; Santi, Daniel V.
- Current Opinion in Biotechnology, Vol. 9, Issue 4, p. 403-411
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula
journal, August 2004
- Chang, Zunxue; Sitachitta, Namthip; Rossi, James V.
- Journal of Natural Products, Vol. 67, Issue 8, p. 1356-1367
Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42
journal, May 2006
- Chen, X.-H.; Vater, J.; Piel, J.
- Journal of Bacteriology, Vol. 188, Issue 11, p. 4024-4036
Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412
journal, October 2008
- Choi, Si-Sun; Kim, Eung-Soo
- Journal of Biotechnology, Vol. 136, S57
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
journal, May 2009
- Erb, T. J.; Brecht, V.; Fuchs, G.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 22, p. 8871-8876
Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis
journal, November 2009
- Gu, Liangcai; Wang, Bo; Kulkarni, Amol
- Journal of the American Chemical Society, Vol. 131, Issue 44, p. 16033-16035
Modular Synthase-Encoding Gene Involved in α-Olefin Biosynthesis in Synechococcus sp. Strain PCC 7002
journal, April 2011
- Mendez-Perez, Daniel; Begemann, Matthew B.; Pfleger, Brian F.
- Applied and Environmental Microbiology, Vol. 77, Issue 12, p. 4264-4267
Biosynthetic engineering of polyketide synthases
journal, October 2003
- Wilkinson, Barrie; Kendrew, Steven G.; Sheridan, Rose M.
- Expert Opinion on Therapeutic Patents, Vol. 13, Issue 10, p. 1579-1606
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis
journal, January 2008
- Zhang, J.; Van Lanen, S. G.; Ju, J.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 5, p. 1460-1465