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Title: Producing alpha-olefins using polyketide synthases

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1415467
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
9,856,461
Application Number:
14/853,821
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2015 Sep 14
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Works referenced in this record:

Engineering of modular polyketide synthases to produce novel polyketides
journal, August 1998

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
journal, May 2009
  • Erb, T. J.; Brecht, V.; Fuchs, G.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 22, p. 8871-8876
  • DOI: 10.1073/pnas.0903939106

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis
journal, January 2008
  • Zhang, J.; Van Lanen, S. G.; Ju, J.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 5, p. 1460-1465
  • DOI: 10.1073/pnas.0711625105