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Title: Amplification of biological targets via on-chip culture for biosensing

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1415449
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL-A
Patent Number(s):
9,857,370
Application Number:
14/157,378
Contract Number:
AC04-94AL85000
Resource Relation:
Patent File Date: 2014 Jan 16
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Point-of-care nucleic acid testing for infectious diseases
journal, May 2011

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008
  • Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
  • Biosensors and Bioelectronics, Vol. 23, Issue 6, p. 757-764
  • DOI: 10.1016/j.bios.2007.08.013

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