Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them
Abstract
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1411431
- Patent Number(s):
- 9834775
- Application Number:
- 15/025,406
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-02ER63445
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Sep 26
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Church, George M., Mandell, Daniel J., and Lajoie, Marc J. Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them. United States: N. p., 2017.
Web.
Church, George M., Mandell, Daniel J., & Lajoie, Marc J. Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them. United States.
Church, George M., Mandell, Daniel J., and Lajoie, Marc J. Tue .
"Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them". United States. https://www.osti.gov/servlets/purl/1411431.
@article{osti_1411431,
title = {Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them},
author = {Church, George M. and Mandell, Daniel J. and Lajoie, Marc J.},
abstractNote = {Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {12}
}
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