Title: Optofluidic devices and methods for sensing single particles

Abstract

This disclosure provides systems, methods, and apparatus related to optofluidic devices. In one aspect, an optofluidic device includes a substrate, a first nanostructure, a second nanostructure, and a cover. A channel having cross-sectional dimensions of less than about 100 nanometers is defined in a surface of the substrate. The first nanostructure is disposed on the substrate on a first side of the channel and proximate the channel. The second nanostructure is disposed on the substrate on a second side of the channel and proximate the channel. The first and the second nanostructures are disposed on a line that passes across the channel. The cover is disposed on the surface of the substrate.

Inventors:

Fernandez-Cuesta, Irene; Cabrini, Stefano

Issue Date:

2017-11-28

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1410540

Patent Number(s):

9829425

Application Number:

14/253,051

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/0663 - Stretching or orienting elongated molecules or particles
B01L2300/0877 - Flow chambers
B01L2300/0896 - Nanoscaled
B01L3/502707 - {characterised by the manufacture of the container or its components
B01L3/502761 - {specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N15/1434 - {using an analyser being characterised by its optical arrangement}
G01N15/1459 - {the analysis being performed on a sample stream}
G01N15/1484 - {microstructural devices}
G01N2015/0038 - {Investigating nanoparticles}
G01N2021/6439 - {with indicators, stains, dyes, tags, labels, marks}
G01N21/648 - {using evanescent coupling or surface plasmon coupling for the excitation of fluorescence}
G01N21/658 - {enhancement Raman, e.g. surface plasmons}

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 2014 Apr 15

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE; 42 ENGINEERING