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Title: Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
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Issue Date:
OSTI Identifier:
Duke University (Durham, NC); Los Alamos National Security, LLC (Los Alamos, NM); The UAB Research Foundation (Birmingham, AL); Beth Israel Deaconess Medical Center (Boston, MA) LANL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2015 Apr 17
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Identification of Highly Conserved and Broadly Cross-Reactive HIV Type 1 Cytotoxic T Lymphocyte Epitopes as Candidate Immunogens for Inclusion in Mycobacterium bovis BCG-Vectored HIV Vaccines
journal, September 2000
  • Ferrari, Guido; Kostyu, Donna D.; Cox, Josephine
  • AIDS Research and Human Retroviruses, Vol. 16, Issue 14, p. 1433-1443
  • DOI: 10.1089/08892220050140982

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
journal, November 2002
  • Altfeld, Marcus; Allen, Todd M.; Yu, Xu G.
  • Nature, Vol. 420, Issue 6914, p. 434-439
  • DOI: 10.1038/nature01200

A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1
journal, May 2005
  • Ammaranond, Palanee; Zaunders, John; Satchell, Claudette
  • AIDS Research and Human Retroviruses, Vol. 21, Issue 5, p. 395-397
  • DOI: 10.1089/aid.2005.21.395

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
  • Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
  • Nature Medicine, Vol. 16, Issue 3, p. 319-323
  • DOI: 10.1038/nm.2089

Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys
journal, July 2003

Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition
journal, March 2005

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway
journal, December 2002
  • Blagoveshchenskaya, Anastassia D.; Thomas, Laurel; Feliciangeli, Sylvain F.
  • Cell, Vol. 111, Issue 6, p. 853-866
  • DOI: 10.1016/S0092-8674(02)01162-5

Prospects for an AIDS vaccine
journal, March 2004
  • Desrosiers, Ronald C.
  • Nature Medicine, Vol. 10, Issue 3, p. 221-223
  • DOI: 10.1038/nm0304-221

HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response
journal, June 2005

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
  • Fischer, Will; Perkins, Simon; Theiler, James
  • Nature Medicine, Vol. 13, Issue 1, p. 100-106
  • DOI: 10.1038/nm1461

Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities
journal, February 2004

Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
journal, December 2004

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002
  • Gaschen, Brian; Taylor, Jesse; Yusim, Karina
  • Science, Vol. 296, Issue 5577, p. 2354-2360
  • DOI: 10.1126/science.1070441

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
journal, September 2009
  • Go, Eden P.; Chang, Qing; Liao, Hua-Xin
  • Journal of Proteome Research, Vol. 8, Issue 9, p. 4231-4242
  • DOI: 10.1021/pr9002728

Codon usage limitation in the expression of HIV-1 envelope glycoprotein
journal, March 1996

Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes
journal, December 2005
  • Hel, Z.; Tsai, W.-P.; Tryniszewska, E.
  • The Journal of Immunology, Vol. 176, Issue 1, p. 85-96
  • DOI: 10.4049/jimmunol.176.1.85

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
journal, December 2004
  • Kiepiela, Photini; Leslie, Alasdair J.; Honeyborne, Isobella
  • Nature, Vol. 432, Issue 7018, p. 769-775
  • DOI: 10.1038/nature03113

Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysis
journal, January 2005

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008
  • Kong, W.-P.; Wu, L.; Wallstrom, T. C.
  • Journal of Virology, Vol. 83, Issue 5, p. 2201-2215
  • DOI: 10.1128/JVI.02256-08

Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines
journal, November 2003

Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009
  • Korber, B. T.; Letvin, N. L.; Haynes, B. F.
  • Journal of Virology, Vol. 83, Issue 17, p. 8300-8314
  • DOI: 10.1128/JVI.00114-09

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
journal, September 2006

HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
journal, January 2004

Hierarchical Targeting of Subtype C Human Immunodeficiency Virus Type 1 Proteins by CD8+ T Cells: Correlation with Viral Load
journal, March 2004

CD8+ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef
journal, September 2005

Urgently needed: a filter for the HIV-1 vaccine pipeline
journal, August 2004
  • Moore, John P.; Burton, Dennis R.
  • Nature Medicine, Vol. 10, Issue 8, p. 769-771
  • DOI: 10.1038/nm0804-769

Fine Specificity and Cross-Clade Reactivity of HIV Type 1 Gag-Specific CD4+ T Cells
journal, March 2004
  • Norris, Philip J.; Moffett, Howell F.; Brander, Christian
  • AIDS Research and Human Retroviruses, Vol. 20, Issue 3, p. 315-325
  • DOI: 10.1089/088922204322996554

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Recombination in HIV-1
journal, March 1995
  • Robertson, David L.; Sharp, Paul M.; McCutchan, Francine E.
  • Nature, Vol. 374, Issue 6518, p. 124-126
  • DOI: 10.1038/374124b0

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008
  • Santra, S.; Korber, B. T.; Muldoon, M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 30, p. 10489-10494
  • DOI: 10.1073/pnas.0803352105

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
  • Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
  • Nature Medicine, Vol. 16, Issue 3, p. 324-328
  • DOI: 10.1038/nm.2108

Use of T Cell Epitopes for Vaccine Development
journal, November 2001
  • Sbai, H.; Mehta, A.; DeGroot, A.
  • Current Drug Target -Infectious Disorders, Vol. 1, Issue 3, p. 303-313
  • DOI: 10.2174/1568005014605955

Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys
journal, February 2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization
journal, December 2002
  • Singh, R. A. K.; Rodgers, J. R.; Barry, M. A.
  • The Journal of Immunology, Vol. 169, Issue 12, p. 6779-6786
  • DOI: 10.4049/jimmunol.169.12.6779

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen
journal, June 2006
  • Weaver, E. A.; Lu, Z.; Camacho, Z. T.
  • Journal of Virology, Vol. 80, Issue 14, p. 6745-6756
  • DOI: 10.1128/JVI.02484-05

Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development
journal, February 2003
  • Williamson, Carolyn; Morris, Lynn; Maughan, Maureen F.
  • AIDS Research and Human Retroviruses, Vol. 19, Issue 2, p. 133-144
  • DOI: 10.1089/088922203762688649