Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

Korber, Bette T.; Fischer, William; Liao, Hua-Xin; Haynes, Barton F.; Letvin, Norman; Hahn, Beatrice H.

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Title: Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

Abstract

The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.

Inventors:: Korber, Bette T.; Fischer, William; Liao, Hua-Xin; Haynes, Barton F.; Letvin, Norman; Hahn, Beatrice H.

Issue Date:: 2017-11-21

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1410329

Patent Number(s):: 9821053

Application Number:: 14/689,995

Assignee:: Duke University (Durham, NC); Los Alamos National Security, LLC (Los Alamos, NM); The UAB Research Foundation (Birmingham, AL); Beth Israel Deaconess Medical Center (Boston, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2039/53 - {DNA
A61K2039/70 - {Multivalent vaccine}
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/12 - Antivirals
A61P31/18 - for HIV
A61P37/00 - Drugs for immunological or allergic disorders
A61P37/04 - Immunostimulants

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/005 - from viruses

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2710/24143 - viral genome or elements thereof as genetic vector
C12N2740/16022 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16034 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16122 - New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N2740/16134 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16234 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N2740/16334 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N7/00 - Viruses

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DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2015 Apr 17

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Korber, Bette T., Fischer, William, Liao, Hua-Xin, Haynes, Barton F., Letvin, Norman, and Hahn, Beatrice H. Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins.  United States: N. p., 2017. 
        Web.

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                    Korber, Bette T., Fischer, William, Liao, Hua-Xin, Haynes, Barton F., Letvin, Norman, & Hahn, Beatrice H. Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins.  United States.

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                    Korber, Bette T., Fischer, William, Liao, Hua-Xin, Haynes, Barton F., Letvin, Norman, and Hahn, Beatrice H. Tue .  
        "Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins".  United States.  https://www.osti.gov/servlets/purl/1410329.

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@article{osti_1410329,

  title        = {Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins},

  author       = {Korber, Bette T. and Fischer, William and Liao, Hua-Xin and Haynes, Barton F. and Letvin, Norman and Hahn, Beatrice H.},

  abstractNote = {The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {11}

}

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Santra, S.; Korber, B. T.; Muldoon, M.
Proceedings of the National Academy of Sciences, Vol. 105, Issue 30, p. 10489-10494
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Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
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Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
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https://doi.org/10.1038/nm.2108

Use of T Cell Epitopes for Vaccine Development
journal, November 2001

Sbai, H.; Mehta, A.; DeGroot, A.
Current Drug Target -Infectious Disorders, Vol. 1, Issue 3, p. 303-313
https://doi.org/10.2174/1568005014605955

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8⁺ Lymphocytes
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Schmitz, Jorn E.; Kuroda, Marcelo J.; Santra, Sampa
Science, Vol. 283, Issue 5403, p. 857-860
https://doi.org/10.1126/science.283.5403.857

Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys
journal, February 2005

Seaman, M. S.; Xu, L.; Beaudry, K.
Journal of Virology, Vol. 79, Issue 5, p. 2956-2963
https://doi.org/10.1128/JVI.79.5.2956-2963.2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

Shinoda, Kaori; Xin, Ke-Qin; Jounai, Nao
Vaccine, Vol. 22, Issue 27-28, p. 3676-3690
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The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization
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Singh, R. A. K.; Rodgers, J. R.; Barry, M. A.
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Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
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Tomaras, G. D.; Yates, N. L.; Liu, P.
Journal of Virology, Vol. 82, Issue 24, p. 12449-12463
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Toward an AIDS Vaccine
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Walker, Bruce D.; Burton, Dennis R.
Science, Vol. 320, Issue 5877, p. 760-764
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Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen
journal, June 2006

Weaver, E. A.; Lu, Z.; Camacho, Z. T.
Journal of Virology, Vol. 80, Issue 14, p. 6745-6756
https://doi.org/10.1128/JVI.02484-05

Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development
journal, February 2003

Williamson, Carolyn; Morris, Lynn; Maughan, Maureen F.
AIDS Research and Human Retroviruses, Vol. 19, Issue 2, p. 133-144
https://doi.org/10.1089/088922203762688649

Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation
journal, September 2002

Yusim, K.; Kesmir, C.; Gaschen, B.
Journal of Virology, Vol. 76, Issue 17, p. 8757-8768
https://doi.org/10.1128/JVI.76.17.8757-8768.2002

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Title: Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

Abstract

Citation Formats

Delivery of exogenous DNA sequences in a mammal patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence patent, December 1996

Generation of antibodies through lipid mediated DNA delivery patent, December 1997

Stabilized viral envelope proteins and uses thereof patent, March 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions patent, February 2010

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins patent, February 2012

Human immunodeficiency virus type 1 clade M mosaic gag polypeptides patent, April 2015

Antigen Library Immunization patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications patent-application, March 2003

Method for the development of an HIV vaccine patent-application, June 2003

Polyvalent immunogen patent-application, August 2003

Immunogenic, cross-clade, HIV peptides patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection patent-application, October 2003

Polyvalent immunogen patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions patent-application, June 2005

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use patent-application, September 2006

HIV vaccines based on Env of multiple clades of HIV patent-application, December 2006

Consensus/ancestral immunogens patent-application, August 2007

Polyvalent Vaccine patent-application, December 2009

Polyvalent Vaccine patent-application, June 2011

Polyvalent Vaccine patent-application, May 2012

Identification of Highly Conserved and Broadly Cross-Reactive HIV Type 1 Cytotoxic T Lymphocyte Epitopes as Candidate Immunogens for Inclusion in Mycobacterium bovis BCG-Vectored HIV Vaccines journal, September 2000

De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection journal, September 2005

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus journal, November 2002

A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1 journal, May 2005

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination journal, October 2000

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys journal, February 2010

Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys journal, July 2003

Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition journal, March 2005

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway journal, December 2002

Prospects for an AIDS vaccine journal, March 2004

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope journal, August 2005

HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response journal, June 2005

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants journal, December 2006

Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities journal, February 2004

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years journal, September 2005

Diversity Considerations in HIV-1 Vaccine Selection journal, June 2002

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins journal, September 2009

Codon usage limitation in the expression of HIV-1 envelope glycoprotein journal, March 1996

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice journal, February 1998

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates journal, January 2014

Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes journal, December 2005

Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response journal, November 2004

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA journal, December 2004

Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysis journal, January 2005

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination journal, December 2008

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T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces journal, May 2009

T Cell Cross-Reactivity and Conformational Changes during TCR Engagement journal, December 2004

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses journal, September 2006

HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity journal, January 2004

HIV VACCINES journal, December 2005

CD8+ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef journal, September 2005

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Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity journal, January 2006

Recombination in HIV-1 journal, March 1995

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys journal, July 2008

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys journal, February 2010

Use of T Cell Epitopes for Vaccine Development journal, November 2001

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes journal, February 1999

Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys journal, February 2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice journal, September 2004

The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization journal, December 2002

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia journal, October 2008

Toward an AIDS Vaccine journal, May 2008

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen journal, June 2006

Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development journal, February 2003

Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation journal, September 2002

Delivery of exogenous DNA sequences in a mammal
patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence
patent, December 1996

Generation of antibodies through lipid mediated DNA delivery
patent, December 1997

Stabilized viral envelope proteins and uses thereof
patent, March 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent, February 2010

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
patent, February 2012

Human immunodeficiency virus type 1 clade M mosaic gag polypeptides
patent, April 2015

Antigen Library Immunization
patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
patent-application, March 2003

Method for the development of an HIV vaccine
patent-application, June 2003

Polyvalent immunogen
patent-application, August 2003

Immunogenic, cross-clade, HIV peptides
patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection
patent-application, October 2003

Polyvalent immunogen
patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
patent-application, September 2006

HIV vaccines based on Env of multiple clades of HIV
patent-application, December 2006

Consensus/ancestral immunogens
patent-application, August 2007

Polyvalent Vaccine
patent-application, December 2009

Polyvalent Vaccine
patent-application, June 2011

Polyvalent Vaccine
patent-application, May 2012

Identification of Highly Conserved and Broadly Cross-Reactive HIV Type 1 Cytotoxic T Lymphocyte Epitopes as Candidate Immunogens for Inclusion in Mycobacterium bovis BCG-Vectored HIV Vaccines
journal, September 2000

De Novo Generation of Escape Variant-Specific CD8⁺ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection
journal, September 2005

HIV-1 superinfection despite broad CD⁸⁺ T-cell responses containing replication of the primary virus
journal, November 2002

A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1
journal, May 2005

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
journal, October 2000

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010

Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys
journal, July 2003

Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition
journal, March 2005

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway
journal, December 2002

Prospects for an AIDS vaccine
journal, March 2004

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
journal, August 2005

HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response
journal, June 2005

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006

Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities
journal, February 2004

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
journal, September 2009

Codon usage limitation in the expression of HIV-1 envelope glycoprotein
journal, March 1996

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice
journal, February 1998

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014

Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes
journal, December 2005

Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8⁺ Cytotoxic T Lymphocyte Response
journal, November 2004

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journal, December 2004

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journal, January 2005

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journal, December 2008

Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines
journal, November 2003

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journal, September 2001

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009

T Cell Cross-Reactivity and Conformational Changes during TCR Engagement
journal, December 2004

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
journal, September 2006

HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
journal, January 2004

HIV VACCINES
journal, December 2005

CD⁸⁺ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef
journal, September 2005

Urgently needed: a filter for the HIV-1 vaccine pipeline
journal, August 2004

HIV vaccine strategies
journal, February 2002

Fine Specificity and Cross-Clade Reactivity of HIV Type 1 Gag-Specific CD4⁺ T Cells
journal, March 2004

HIV‐Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4⁺ T Cells in Relation to HIV RNA Load
journal, April 2004

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Recombination in HIV-1
journal, March 1995

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008

Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010

Use of T Cell Epitopes for Vaccine Development
journal, November 2001

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8⁺ Lymphocytes
journal, February 1999

Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys
journal, February 2005

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization
journal, December 2002

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
journal, October 2008

Toward an AIDS Vaccine
journal, May 2008

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen
journal, June 2006

Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development
journal, February 2003

Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation
journal, September 2002