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Title: Ion funnel device

An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1409832
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
Patent Number(s):
9,824,874
Application Number:
14/733,517
Contract Number:
AC05-76RL01830
Resource Relation:
Patent File Date: 2015 Jun 08
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 24 POWER TRANSMISSION AND DISTRIBUTION

Works referenced in this record:

A simple electrospray interface based on a DC ion carpet
journal, October 2014
  • Anthony, Staci N.; Shinholt, Deven L.; Jarrold, Martin F.
  • International Journal of Mass Spectrometry, Vol. 371, p. 1-7
  • DOI: 10.1016/j.ijms.2014.06.007

Ion mobility spectrometry—mass spectrometry performance using electrodynamic ion funnels and elevated drift gas pressures
journal, July 2007
  • Baker, Erin Shammel; Clowers, Brian H.; Li, Fumin
  • Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 7, p. 1176-1187
  • DOI: 10.1016/j.jasms.2007.03.031

Initial implementation of an electrodynamic ion funnel with fourier transform ion cyclotron resonance mass spectrometry
journal, January 2000
  • Belov, Mikhail E.; Gorshkov, Michael V.; Udseth, Harold R.
  • Journal of the American Society for Mass Spectrometry, Vol. 11, Issue 1, p. 19-23
  • DOI: 10.1016/S1044-0305(99)00121-X

Mass spectrometry with ion sources operating at atmospheric pressure
journal, January 1991

Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry
journal, February 2008
  • Clowers, Brian H.; Ibrahim, Yehia M.; Prior, David C.
  • Analytical Chemistry, Vol. 80, Issue 3, p. 612-623
  • DOI: 10.1021/ac701648p

Some Thoughts on Electrospray Ionization Mechanisms
journal, April 2011
  • Crotti, Sara; Seraglia, Roberta; Traldi, Pietro
  • European Journal of Mass Spectrometry, Vol. 17, Issue 2, p. 85-99
  • DOI: 10.1255/ejms.1129

Collisional focusing effects in radio frequency quadrupoles
journal, May 1992
  • Douglas, D. J.; French, J. B.
  • Journal of the American Society for Mass Spectrometry, Vol. 3, Issue 4, p. 398-408
  • DOI: 10.1016/1044-0305(92)87067-9

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989

Electrospray ionization-principles and practice
journal, January 1990
  • Fenn, John B.; Mann, Matthias; Meng, Chin Kai
  • Mass Spectrometry Reviews, Vol. 9, Issue 1, p. 37-70
  • DOI: 10.1002/mas.1280090103

Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)
journal, September 2014
  • Garimella, Sandilya V. B.; Ibrahim, Yehia M.; Webb, Ian K.
  • Journal of The American Society for Mass Spectrometry, Vol. 25, Issue 11, p. 1890-1896
  • DOI: 10.1007/s13361-014-0976-y

Ion Mobility-Mass Spectrometry Analysis of Serum N-linked Glycans from Esophageal Adenocarcinoma Phenotypes
journal, October 2012
  • Gaye, M. M.; Valentine, S. J.; Hu, Y.
  • Journal of Proteome Research, Vol. 11, Issue 12, p. 6102-6110
  • DOI: 10.1021/pr300756e

Stacked-ring electrostatic ion guide
journal, January 1996
  • Guan, Shenheng; Marshall, Alan G.
  • Journal of the American Society for Mass Spectrometry, Vol. 7, Issue 1, p. 101-106
  • DOI: 10.1016/1044-0305(95)00605-2

Applications of ESI-MS in drug discovery: interrogation of noncovalent complexes
journal, July 2006
  • Hofstadler, Steven A.; Sannes-Lowery, Kristin A.
  • Nature Reviews Drug Discovery, Vol. 5, Issue 7, p. 585-595
  • DOI: 10.1038/nrd2083

Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
journal, September 2006
  • Ibrahim, Yehia; Tang, Keqi; Tolmachev, Aleksey V.
  • Journal of the American Society for Mass Spectrometry, Vol. 17, Issue 9, p. 1299-1305
  • DOI: 10.1016/j.jasms.2006.06.005

Ion funnels for the masses: Experiments and simulations with a simplified ion funnel
journal, October 2005
  • Julian, Ryan R.; Mabbett, Sarah R.; Jarrold, Martin F.
  • Journal of the American Society for Mass Spectrometry, Vol. 16, Issue 10, p. 1708-1712
  • DOI: 10.1016/j.jasms.2005.06.012

Chemically Etched Open Tubular and Monolithic Emitters for Nanoelectrospray Ionization Mass Spectrometry
journal, November 2006
  • Kelly, Ryan T.; Page, Jason S.; Luo, Quanzhou
  • Analytical Chemistry, Vol. 78, Issue 22, p. 7796-7801
  • DOI: 10.1021/ac061133r

The ion funnel: Theory, implementations, and applications
journal, April 2009
  • Kelly, Ryan T.; Tolmachev, Aleksey V.; Page, Jason S.
  • Mass Spectrometry Reviews, Vol. 29, Issue 2, p. 294-312
  • DOI: 10.1002/mas.20232

A new, higher resolution, ion mobility mass spectrometer
journal, October 2009
  • Kemper, Paul R.; Dupuis, Nicholas F.; Bowers, Michael T.
  • International Journal of Mass Spectrometry, Vol. 287, Issue 1-3, p. 46-57
  • DOI: 10.1016/j.ijms.2009.01.012

An IMS−IMS Analogue of MS−MS
journal, June 2006
  • Koeniger, Stormy L.; Merenbloom, Samuel I.; Valentine, Stephen J.
  • Analytical Chemistry, Vol. 78, Issue 12, p. 4161-4174
  • DOI: 10.1021/ac051060w

Conformational Ordering of Biomolecules in the Gas Phase: Nitrogen Collision Cross Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer
journal, February 2014
  • May, Jody C.; Goodwin, Cody R.; Lareau, Nichole M.
  • Analytical Chemistry, Vol. 86, Issue 4, p. 2107-2116
  • DOI: 10.1021/ac4038448

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface
journal, September 2007
  • Page, Jason S.; Kelly, Ryan T.; Tang, Keqi
  • Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 9, p. 1582-1590
  • DOI: 10.1016/j.jasms.2007.05.018

Characterization of an Improved Electrodynamic Ion Funnel Interface for Electrospray Ionization Mass Spectrometry
journal, August 1999
  • Shaffer, Scott A.; Tolmachev, Aleksey; Prior, David C.
  • Analytical Chemistry, Vol. 71, Issue 15, p. 2957-2964
  • DOI: 10.1021/ac990346w

An Ion Funnel Interface for Improved Ion Focusing and Sensitivity Using Electrospray Ionization Mass Spectrometry
journal, October 1998
  • Shaffer, Scott A.; Prior, David C.; Anderson, Gordon A.
  • Analytical Chemistry, Vol. 70, Issue 19, p. 4111-4119
  • DOI: 10.1021/ac9802170

Ultrasensitive Proteomics Using High-Efficiency On-Line Micro-SPE-NanoLC-NanoESI MS and MS/MS
journal, January 2004
  • Shen, Yufeng; Tolić, Nikola; Masselon, Christophe
  • Analytical Chemistry, Vol. 76, Issue 1, p. 144-154
  • DOI: 10.1021/ac030096q

Measuring the Resolving Power of Ion Mobility Spectrometers
journal, December 1994
  • Siems, William F.; Wu, Ching.; Tarver, Edward E.
  • Analytical Chemistry, Vol. 66, Issue 23, p. 4195-4201
  • DOI: 10.1021/ac00095a014

High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces
journal, May 2005
  • Tang, Keqi; Shvartsburg, Alexandre A.; Lee, Hak-No
  • Analytical Chemistry, Vol. 77, Issue 10, p. 3330-3339
  • DOI: 10.1021/ac048315a

Characterization of Ion Dynamics in Structures for Lossless Ion Manipulations
journal, September 2014
  • Tolmachev, Aleksey V.; Webb, Ian K.; Ibrahim, Yehia M.
  • Analytical Chemistry, Vol. 86, Issue 18, p. 9162-9168
  • DOI: 10.1021/ac502054p

Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry
journal, September 2014
  • Webb, Ian K.; Garimella, Sandilya V. B.; Tolmachev, Aleksey V.
  • Analytical Chemistry, Vol. 86, Issue 18, p. 9169-9176
  • DOI: 10.1021/ac502055e

Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry: Dynamic Switching in Structures for Lossless Ion Manipulations
journal, September 2014
  • Webb, Ian K.; Garimella, Sandilya V. B.; Tolmachev, Aleksey V.
  • Analytical Chemistry, Vol. 86, Issue 19, p. 9632-9637
  • DOI: 10.1021/ac502139e