Title: Recombinant host cells for the production of malonate

Abstract

Systems and methods for the production of malonate in recombinant host cells.

Inventors:

Dietrich, Jeffrey A.; Fortman, Jeffrey L.; Steen, Eric J.

Issue Date:

Tue Nov 14 00:00:00 EST 2017

Research Org.:

Lygos, Inc., San Francisco, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1409010

Patent Number(s):

9816114

Application Number:

14/386,272

Assignee:

Lygos, Inc. (San Francisco, CA)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C51/38 - by decarboxylation
C07C57/04 - Acrylic acid
C07C67/08 - by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
C07C67/31 - by introduction of functional groups containing oxygen only in singly bound form
C07C69/38 - Malonic acid esters
C07C69/675 - of saturated hydroxy-carboxylic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N9/16 - acting on ester bonds

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

C12P7/46 - Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y301/02004 - 3-Hydroxyisobutyryl-CoA hydrolase

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DOE Contract Number:  

SC0006469

Resource Type:

Patent

Resource Relation:

Patent File Date: 2013 Mar 06

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY