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Title: Methods and apparatus for analysis of chromatographic migration patterns

Abstract

A method and apparatus are presented for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means. 16 figures.

Inventors:
;
Issue Date:
Research Org.:
Univ. of Utah, Salt Lake City, UT (United States)
OSTI Identifier:
140713
Patent Number(s):
5,273,632
Assignee:
Univ. of Utah Research Foundation, Salt Lake City, UT (United States)
DOE Contract Number:  
FG02-88ER60700
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 28 Dec 1993
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; ELECTROPHORESIS; DESIGN; IMAGE PROCESSING; CHROMATOGRAPHY; DNA SEQUENCERS; MEASURING METHODS; TECHNOLOGY ASSESSMENT

Citation Formats

Stockham, T G, and Ives, J T. Methods and apparatus for analysis of chromatographic migration patterns. United States: N. p., 1993. Web.
Stockham, T G, & Ives, J T. Methods and apparatus for analysis of chromatographic migration patterns. United States.
Stockham, T G, and Ives, J T. Tue . "Methods and apparatus for analysis of chromatographic migration patterns". United States.
@article{osti_140713,
title = {Methods and apparatus for analysis of chromatographic migration patterns},
author = {Stockham, T G and Ives, J T},
abstractNote = {A method and apparatus are presented for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means. 16 figures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {12}
}