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Title: Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions

Abstract

A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1406520
Patent Number(s):
RE46,594
Application Number:
14/289,445
Assignee:
LOS ALAMOS NATIONAL SECURITY, LLC
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 May 28
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States: N. p., 2017. Web.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., & Akhadov, Elshan A. Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions. United States.
Sansinena, Jose-Maria, Redondo, Antonio, Olazabal, Virginia, Hoffbauer, Mark A., and Akhadov, Elshan A. Tue . "Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions". United States. https://www.osti.gov/servlets/purl/1406520.
@article{osti_1406520,
title = {Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions},
author = {Sansinena, Jose-Maria and Redondo, Antonio and Olazabal, Virginia and Hoffbauer, Mark A. and Akhadov, Elshan A.},
abstractNote = {A barrier structure for use in an electrochemical stochastic membrane sensor for single molecule detection. The sensor is based upon inorganic nanopores having electrically tunable dimensions. The inorganic nanopores are formed from inorganic materials and an electrically conductive polymer. Methods of making the barrier structure and sensing single molecules using the barrier structure are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 31 00:00:00 EDT 2017},
month = {Tue Oct 31 00:00:00 EDT 2017}
}

Works referenced in this record:

Methods and apparatus for characterizing polynucleotides
patent, July 2007


Methods of fabrication employing nanoscale mandrels
patent, June 2009


Capillary electrophoresis method
patent, December 2009


Electrochemical detection of single molecules using abiotic nanopores having electrically tunable dimensions
patent, December 2009


Method and apparatus for combined electrochemical synthesis and detection of analytes
patent, April 2011


Method and apparatus for analysis of biological solutions
patent-application, October 2002


Small molecule microarrays
patent-application, February 2003


Nanostructured material transport devices and their fabrication by application of molecular coatings to nanoscale channels
patent-application, February 2005


Molecular resonant tunneling sensor and methods of fabricating and using the same
patent-application, October 2006


Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis
patent-application, December 2006


Nanopore sensor system
patent-application, December 2007


Method and apparatus for combined electrochemical synthesis and detection of analytes
patent-application, July 2008


Microarray Device
patent-application, December 2008


Formation of Layers of Amphiphilic Molecules
patent-application, July 2009


Electrochemical Detection Of Single Molecules Using Abiotic Nanopores Having Electrically Tunable Dimensions
patent-application, November 2009


Nanopore Based Ion-Selective Electrodes
patent-application, February 2010


Immobilized Nucleic Acid Complexes For Sequence Analysis
patent-application, March 2010


Devices And Methods For Analyzing Biomolecules And Probes Bound Thereto
patent-application, December 2010


Nanofludic Field Effect Transistor Based On Surface Charge Modulated Nanochannel
patent-application, December 2010


Nanopore Sequencing Devices And Methods
patent-application, December 2010


Conductivity sensor device comprising diamond film with at least one nanopore or micorpore
patent-application, May 2011


Method Of Fabrication Of Monolithic Stationary Phases For Separations, And Methods Of Separation Using Such Stationary Phases
patent-application, December 2011


Multiple Walled Nested Coaxial Nanostructures
patent-application, February 2012


Nanopore-Based Nanoparticle Translocation Devices
patent-application, April 2012


Controlling Translocation Through Nanopores With Fluid Wall
patent-application, February 2013


A biosensor that uses ion-channel switches
June 1997


Conducting polymer polypyrrole supported bilayer lipid membranes
journal, January 2005


Reversible Conversion of Conducting Polymer Films from Superhydrophobic to Superhydrophilic
journal, September 2005


Continuous base identification for single-molecule nanopore DNA sequencing
journal, February 2009


Electrooxidative Deposition of Polypyrrole and Polyaniline on Self-Assembled Monolayer Modified Electrodes
journal, February 1997


Stochastic sensors inspired by biology
journal, September 2001


Synthesis of heterosegment-junctioned hybrid nanotubes of polythiophene and heterometallic nanoparticles by sequential template-based electropolymerization
journal, January 2011


Resistive-Pulse Sensing - From Microbes to Molecules
journal, July 2000


Single Ion Channel Sensitivity in Suspended Bilayers on Micromachined Supports
journal, February 2001


An Asymmetric Polymer Nanopore for Single Molecule Detection
journal, March 2004


Ion-beam sculpting at nanometre length scales
journal, July 2001


An Artificial Nanopore for Molecular Sensing
journal, January 2003