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Title: Unnatural reactive amino acid genetic code additions

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1404921
Patent Number(s):
9797908
Application Number:
14/338,113
Assignee:
The Scripps Research Institute
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jul 22
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, Christopher J., and Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States: N. p., 2017. Web.
Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, Christopher J., & Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States.
Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, Christopher J., and Schultz, Peter G. Wed . "Unnatural reactive amino acid genetic code additions". United States. https://www.osti.gov/servlets/purl/1404921.
@article{osti_1404921,
title = {Unnatural reactive amino acid genetic code additions},
author = {Deiters, Alexander and Cropp, T. Ashton and Chin, Jason W. and Anderson, Christopher J. and Schultz, Peter G.},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {10}
}

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