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Title: Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry

The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.
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Issue Date:
OSTI Identifier:
The Regents of The University of California LBNL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2013 Dec 20
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
Country of Publication:
United States

Other works cited in this record:

Capillary electrophoresis electrospray ionization mass spectrometry interface
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Apparatus and method for high throughput electrorotation analysis
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Method of making a thick microstructural oxide layer
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Microfluidic chip with enhanced tip for stable electrospray ionization
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Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer
patent, June 2008

Charging device and image forming device using same
patent, June 2011

Monolithic multinozzle emitters for nanoelectrospray mass spectrometry
patent, September 2011

Microchips with integrated multiple electrospray ionization emitters and related methods, systems and devices
patent, April 2015

Method and apparatus for dispensing small volume of liquid, such as with a wetting-resistant nozzle
patent-application, July 2002

Electrospray interface
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Microdevice having an annular lining for producing an electrospray emitter
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Apparatus for Dispensing a Sample in Electrospray Mass Spectrometers
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Integrated Apparatus for Performing Nucleic Acid Extraction and Diagnostic Testing on Multiple Biological Samples
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Electrospray Evaporative Cooling (ESC)
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Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry
patent-application, March 2010

Apparatus and Methods for Pneumatically-Assisted Electrospray Emitter Array
patent-application, June 2011

Chromatography Apparatus Having Diffusion-Bonded and Surface-Modified Components
patent-application, January 2013

Cartridge with Multiple Electrospray Emitters
patent-application, February 2014

A clean wafer-scale chip-release process without dicing based on vapor phase etching
conference, January 2004

Multinozzle Emitter Arrays for Nanoelectrospray Mass Spectrometry
journal, August 2011
  • Mao, Pan; Wang, Hung-Ta; Yang, Peidong
  • Analytical Chemistry, Vol. 83, Issue 15, p. 6082-6089
  • DOI: 10.1021/ac2011813

A Fully Integrated Monolithic Microchip Electrospray Device for Mass Spectrometry
journal, September 2000
  • Schultz, Gary A.; Corso, Thomas N.; Prosser, Simon J.
  • Analytical Chemistry, Vol. 72, Issue 17, p. 4058-4063
  • DOI: 10.1021/ac000325y

Nanoelectrospray emitters: Trends and perspective
journal, November 2009
  • Gibson, Graham T. T.; Mugo, Samuel M.; Oleschuk, Richard D.
  • Mass Spectrometry Reviews, Vol. 28, Issue 6, p. 918-936
  • DOI: 10.1002/mas.20248

High-throughput analysis using gated multi-inlet mass spectrometry
journal, February 2011
  • Moini, Mehdi; Jiang, Longfei; Bootwala, Samir
  • Rapid Communications in Mass Spectrometry, Vol. 25, Issue 6, p. 789-794
  • DOI: 10.1002/rcm.4924

Microfabricated Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry
journal, May 2007
  • Kim, Woong; Guo, Mingquan; Yang, Peidong
  • Analytical Chemistry, Vol. 79, Issue 10, p. 3703-3707
  • DOI: 10.1021/ac070010j

Electrospray Characteristic Curves:  In Pursuit of Improved Performance in the Nanoflow Regime
journal, November 2007
  • Marginean, Ioan; Kelly, Ryan T.; Page, Jason S.
  • Analytical Chemistry, Vol. 79, Issue 21, p. 8030-8036
  • DOI: 10.1021/ac0707986

Elastomeric Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nanoflow Regime
journal, May 2008
  • Kelly, Ryan T.; Tang, Keqi; Irimia, Daniel
  • Analytical Chemistry, Vol. 80, Issue 10, p. 3824-3831
  • DOI: 10.1021/ac8000786

A decade of microfluidic analysis coupled with electrospray mass spectrometry: An overview
journal, January 2007
  • Koster, Sander; Verpoorte, Elisabeth
  • Lab on a Chip, Vol. 7, Issue 11, p. 1394-1412
  • DOI: 10.1039/B709706A

A Micromachined Chip-Based Electrospray Source for Mass Spectrometry
journal, January 2000
  • Licklider, Larry; Wang, Xuan-Qi; Desai, Amish
  • Analytical Chemistry, Vol. 72, Issue 2, p. 367-375
  • DOI: 10.1021/ac990967p

Quantitative Mass Spectrometric Determination of Methylphenidate Concentration in Urine Using an Electrospray Ionization Source Integrated with a Polymer Microchip
journal, May 2004
  • Yang, Yanou; Kameoka, Jun; Wachs, Timothy
  • Analytical Chemistry, Vol. 76, Issue 9, p. 2568-2574
  • DOI: 10.1021/ac0303618

Microfabricated PDMS multichannel emitter for electrospray ionization mass spectrometry
journal, April 2001
  • Kim, Jin-Sung; Knapp, Daniel R.
  • Journal of the American Society for Mass Spectrometry, Vol. 12, Issue 4, p. 463-469
  • DOI: 10.1016/S1044-0305(01)00219-7

A new on-chip ESI nozzle for coupling of MS with microfluidic devices
journal, January 2004
  • Schilling, M.; Nigge, W.; Rudzinski, A.
  • Lab on a Chip, Vol. 4, Issue 3, p. 220-224
  • DOI: 10.1039/B315957B

A novel nib-like design for microfabricated nanospray tips
journal, March 2004
  • Gac, Séverine; Cren-Olivé, Cécile; Rolando, Christian
  • Journal of the American Society for Mass Spectrometry, Vol. 15, Issue 3, p. 409-412
  • DOI: 10.1016/j.jasms.2003.11.001

Multiple electrosprays emitted from an array of holes
journal, December 2005

Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets
journal, June 2006

An Electrospray Method Using a Multi-Capillary Nozzle Emitter
journal, September 2007
  • Tatemoto, Y.; Ishikawa, R.; Takeuchi, M.
  • Chemical Engineering & Technology, Vol. 30, Issue 9, p. 1274-1279
  • DOI: 10.1002/ceat.200700060

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