skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: System and method for detecting components of a mixture including a valving scheme for competition assays

Abstract

Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.

Inventors:
; ;
Issue Date:
Research Org.:
National Technology & Engineering Solutions of Sandia, LLC., Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1393511
Patent Number(s):
9766230
Application Number:
15/616,740
Assignee:
National Technology & Engineering Solutions of Sandia, LLC
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
NA0003525
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Jun 07
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION

Citation Formats

Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K.. System and method for detecting components of a mixture including a valving scheme for competition assays. United States: N. p., 2017. Web.
Koh, Chung-Yan, Piccini, Matthew E., & Singh, Anup K.. System and method for detecting components of a mixture including a valving scheme for competition assays. United States.
Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K.. Tue . "System and method for detecting components of a mixture including a valving scheme for competition assays". United States. https://www.osti.gov/servlets/purl/1393511.
@article{osti_1393511,
title = {System and method for detecting components of a mixture including a valving scheme for competition assays},
author = {Koh, Chung-Yan and Piccini, Matthew E. and Singh, Anup K.},
abstractNote = {Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {9}
}

Patent:

Save / Share:

Works referenced in this record:

Ricin A-Chain Activity on Stem−Loop and Unstructured DNA Substrates
journal, March 2005


Parallel Nanoliter Microfluidic Analysis System
journal, June 2007


Cell-Free DNA—A Marker to Predict Ischemic Brain Damage in a Rat Stroke Experimental Model
journal, January 2011


Formation of Natural pH Gradients in a Microfluidic Device under Flow Conditions:  Model and Experimental Validation
journal, February 2001


Multistage Isoelectric Focusing in a Polymeric Microfluidic Chip
journal, December 2005


Effects of separation length and voltage on isoelectric focusing in a plastic microfluidic device
journal, September 2006


Detecting Single Stranded DNA with a Solid State Nanopore
journal, October 2005


On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multidimensional Separations
journal, March 2003


Rapid isoelectric trapping in a micropreparative-scale multicompartment electrolyzer
journal, June 2007