System and method for detecting components of a mixture including a valving scheme for competition assays

Title: System and method for detecting components of a mixture including a valving scheme for competition assays

Abstract

Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.

Inventors:: Koh, Chung-Yan; Piccini, Matthew E.; Singh, Anup K.

Issue Date:: 2017-09-19

Research Org.:: National Technology & Engineering Solutions of Sandia, LLC., Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1393511

Patent Number(s):: 9,766,230

Application Number:: 15/616,740

Assignee:: National Technology & Engineering Solutions of Sandia, LLC

DOE Contract Number:: NA0003525

Resource Type:: Patent

Resource Relation:: Patent File Date: 2017 Jun 07

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION

Citation Formats


                    Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K. System and method for detecting components of a mixture including a valving scheme for competition assays.  United States: N. p., 2017. 
        Web.

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                    Koh, Chung-Yan, Piccini, Matthew E., & Singh, Anup K. System and method for detecting components of a mixture including a valving scheme for competition assays.  United States.

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                    Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K. Tue .  
        "System and method for detecting components of a mixture including a valving scheme for competition assays".  United States.  https://www.osti.gov/servlets/purl/1393511.

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@article{osti_1393511,

  title        = {System and method for detecting components of a mixture including a valving scheme for competition assays},

  author       = {Koh, Chung-Yan and Piccini, Matthew E. and Singh, Anup K.},

  abstractNote = {Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2017},

  month        = {9}

}

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Title: System and method for detecting components of a mixture including a valving scheme for competition assays

Abstract

Citation Formats

Multistation, Single Channel Analytical Photometer and Method Of Use patent, January 1971

Loading disk for photometric analyzer of rotary cuvette type patent, July 1973

Separation of solid and liquid components of mixtures patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood patent, May 1979

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent, November 1985

Heterogeneous binding assay patent, April 1987

Method and apparatus for measuring blood constituent counts patent, July 1987

Method for separating the cellular components of blood samples patent, July 1989

Method of separation employing magnetic particles and second medium patent, January 1994

Assay of blood or other biologic samples for target analytes patent, June 1997

DNA purification and isolation using magnetic particles patent, January 1998

Assay system and method for conducting assays patent, March 1999

Apparatus and method for carrying out analysis of samples patent, April 1999

Centrifugal hematology disposable patent, November 2000

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

Diagnostic tests and kits for Clostridium difficile patent, January 2003

Monolithic microfluidic concentrators and mixers patent, May 2005

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent, November 2005

Multi-parameter assays including analysis discs and methods relating thereto patent, April 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent, January 2007

Microfluidic particle-analysis systems patent, December 2007

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids patent, February 2008

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Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces patent, December 2012

Devices, systems, and methods for conducting sandwich assays using sedimentation patent, February 2015

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force patent, November 2015

Systems, devices, and methods for agglutination assays using sedimentation patent, January 2016

Toxin activity assays, devices, methods and systems therefor patent, April 2016

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent, April 2016

System and method for detecting components of a mixture including tooth elements for alignment patent, November 2016

Ricin A-Chain Activity on Stem−Loop and Unstructured DNA Substrates journal, March 2005

Parallel Nanoliter Microfluidic Analysis System journal, June 2007

Cell-Free DNA—A Marker to Predict Ischemic Brain Damage in a Rat Stroke Experimental Model journal, January 2011

Formation of Natural pH Gradients in a Microfluidic Device under Flow Conditions: Model and Experimental Validation journal, February 2001

Multistage Isoelectric Focusing in a Polymeric Microfluidic Chip journal, December 2005

Effects of separation length and voltage on isoelectric focusing in a plastic microfluidic device journal, September 2006

Detecting Single Stranded DNA with a Solid State Nanopore journal, October 2005

On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multidimensional Separations journal, March 2003

Microfabrication of a tapered channel for isoelectric focusing with thermally generated pH gradient journal, October 2002

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Multistation, Single Channel Analytical Photometer and Method Of Use
patent, January 1971

Loading disk for photometric analyzer of rotary cuvette type
patent, July 1973

Separation of solid and liquid components of mixtures
patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood
patent, May 1979

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device
patent, November 1985

Heterogeneous binding assay
patent, April 1987

Method and apparatus for measuring blood constituent counts
patent, July 1987

Method for separating the cellular components of blood samples
patent, July 1989

Method of separation employing magnetic particles and second medium
patent, January 1994

Assay of blood or other biologic samples for target analytes
patent, June 1997

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patent, January 1998

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patent, March 1999

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patent, April 1999

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patent, November 2000

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patent, November 2001

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patent, January 2003

Monolithic microfluidic concentrators and mixers
patent, May 2005

Class characterization of circulating cancer cells isolated from body fluids and methods of use
patent, November 2005

Multi-parameter assays including analysis discs and methods relating thereto
patent, April 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
patent, January 2007

Microfluidic particle-analysis systems
patent, December 2007

Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
patent, February 2008

Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device
patent, July 2010

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
patent, December 2012

Devices, systems, and methods for conducting sandwich assays using sedimentation
patent, February 2015

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, February 2015

Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
patent, November 2015

Systems, devices, and methods for agglutination assays using sedimentation
patent, January 2016

Toxin activity assays, devices, methods and systems therefor
patent, April 2016

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
patent, April 2016

System and method for detecting components of a mixture including tooth elements for alignment
patent, November 2016

Ricin A-Chain Activity on Stem−Loop and Unstructured DNA Substrates
journal, March 2005

Parallel Nanoliter Microfluidic Analysis System
journal, June 2007

Cell-Free DNA—A Marker to Predict Ischemic Brain Damage in a Rat Stroke Experimental Model
journal, January 2011

Formation of Natural pH Gradients in a Microfluidic Device under Flow Conditions: Model and Experimental Validation
journal, February 2001

Multistage Isoelectric Focusing in a Polymeric Microfluidic Chip
journal, December 2005

Effects of separation length and voltage on isoelectric focusing in a plastic microfluidic device
journal, September 2006

Detecting Single Stranded DNA with a Solid State Nanopore
journal, October 2005

On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multidimensional Separations
journal, March 2003

Microfabrication of a tapered channel for isoelectric focusing with thermally generated pH gradient
journal, October 2002

Rapid isoelectric trapping in a micropreparative-scale multicompartment electrolyzer
journal, June 2007