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Title: Biosensors engineered from conditionally stable ligand-binding domains

Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.
Inventors:
; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1393435
Assignee:
President and Fellows of Harvard College CHO
Patent Number(s):
9,766,255
Application Number:
14/993,509
Contract Number:
FG02-02ER63445
Resource Relation:
Patent File Date: 2016 Jan 12
Research Org:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Computational design of ligand-binding proteins with high affinity and selectivity
journal, September 2013
  • Tinberg, Christine E.; Khare, Sagar D.; Dou, Jiayi
  • Nature, Vol. 501, Issue 7466, p. 212-216
  • DOI: 10.1038/nature12443

Destabilizing Domains Derived from the Human Estrogen Receptor
journal, February 2012
  • Miyazaki, Yusuke; Imoto, Hiroshi; Chen, Ling-chun
  • Journal of the American Chemical Society, Vol. 134, Issue 9, p. 3942-3945
  • DOI: 10.1021/ja209933r

Screening for Enhanced Triacetic Acid Lactone Production by Recombinant Escherichia coli Expressing a Designed Triacetic Acid Lactone Reporter
journal, June 2013
  • Tang, Shuang-Yan; Qian, Shuai; Akinterinwa, Olubolaji
  • Journal of the American Chemical Society, Vol. 135, Issue 27, p. 10099-10103
  • DOI: 10.1021/ja402654z

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