Biosensors engineered from conditionally stable ligand-binding domains
Abstract
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1393435
- Patent Number(s):
- 9766255
- Application Number:
- 14/993,509
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA); University of Washington (Seattle, WA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FG02-02ER63445
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2016 Jan 12
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, and Tinberg, Christine Elaine. Biosensors engineered from conditionally stable ligand-binding domains. United States: N. p., 2017.
Web.
Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, & Tinberg, Christine Elaine. Biosensors engineered from conditionally stable ligand-binding domains. United States.
Church, George M., Feng, Justin, Mandell, Daniel J., Baker, David, Fields, Stanley, Jester, Benjamin Ward, and Tinberg, Christine Elaine. Tue .
"Biosensors engineered from conditionally stable ligand-binding domains". United States. https://www.osti.gov/servlets/purl/1393435.
@article{osti_1393435,
title = {Biosensors engineered from conditionally stable ligand-binding domains},
author = {Church, George M. and Feng, Justin and Mandell, Daniel J. and Baker, David and Fields, Stanley and Jester, Benjamin Ward and Tinberg, Christine Elaine},
abstractNote = {Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {9}
}
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