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Title: Electrospray ionizer for mass spectrometry of aerosol particles

Abstract

A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
MSP Corporation, Shoreview, MN (United States); Univ. of Minnesota, Minneapolis, MN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1393424
Patent Number(s):
9768005
Application Number:
15/135,132
Assignee:
MSP Corporation (Shoreview, MN); Regents of the University of Minnesota (Minneapolis, MN)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
SC0013302
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Apr 21
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 36 MATERIALS SCIENCE

Citation Formats

He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, and Romay, Francisco. Electrospray ionizer for mass spectrometry of aerosol particles. United States: N. p., 2017. Web.
He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, & Romay, Francisco. Electrospray ionizer for mass spectrometry of aerosol particles. United States.
He, Siqin, Hogan, Chris, Li, Lin, Liu, Benjamin Y. H., Naqwi, Amir, and Romay, Francisco. Tue . "Electrospray ionizer for mass spectrometry of aerosol particles". United States. https://www.osti.gov/servlets/purl/1393424.
@article{osti_1393424,
title = {Electrospray ionizer for mass spectrometry of aerosol particles},
author = {He, Siqin and Hogan, Chris and Li, Lin and Liu, Benjamin Y. H. and Naqwi, Amir and Romay, Francisco},
abstractNote = {A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {9}
}

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Works referenced in this record:

Characterizing an Extractive Electrospray Ionization (EESI) Source for the Online Mass Spectrometry Analysis of Organic Aerosols
journal, June 2013


Online Characterization of Particles and Gases with an Ambient Electrospray Ionization Source
journal, September 2012


Electrospray-assisted laser desorption/ionization and tandem mass spectrometry of peptides and proteins
journal, January 2007

  • Peng, Ivory X.; Shiea, Jentaie; Loo, Rachel R. Ogorzalek
  • Rapid Communications in Mass Spectrometry, Vol. 21, Issue 16, p. 2541-2546
  • https://doi.org/10.1002/rcm.3154