Global to push GA events into
skip to main content

Title: Electrospray ionizer for mass spectrometry of aerosol particles

A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1393424
Assignee:
MSP Corporation CHO
Patent Number(s):
9,768,005
Application Number:
15/135,132
Contract Number:
SC0013302
Resource Relation:
Patent File Date: 2016 Apr 21
Research Org:
MSP Corporation, Shoreview, MN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 36 MATERIALS SCIENCE

Works referenced in this record:

Characterizing an Extractive Electrospray Ionization (EESI) Source for the Online Mass Spectrometry Analysis of Organic Aerosols
journal, June 2013
  • Gallimore, Peter J.; Kalberer, Markus
  • Environmental Science & Technology, Vol. 47, Issue 13, p. 7324-7331
  • DOI: 10.1021/es305199h

Online Characterization of Particles and Gases with an Ambient Electrospray Ionization Source
journal, September 2012
  • Horan, Andrew J.; Gao, Yuqian; Hall, Wiley A.
  • Analytical Chemistry, Vol. 84, Issue 21, p. 9253-9258
  • DOI: 10.1021/ac302024y

Electrospray-assisted laser desorption/ionization and tandem mass spectrometry of peptides and proteins
journal, January 2007
  • Peng, Ivory X.; Shiea, Jentaie; Loo, Rachel R. Ogorzalek
  • Rapid Communications in Mass Spectrometry, Vol. 21, Issue 16, p. 2541-2546
  • DOI: 10.1002/rcm.3154

Synthesis, crystal structure, insecticidal activity and DFT study on the geometry and vibration of O-(E)-1-{1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethyleneamino-O-ethyl-O-phenylphosphorothioate
journal, December 2008
  • Shi, De-Qing; Zhu, Xiao-Fei; Song, Yuan-Zhi
  • Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 71, Issue 3, p. 1011-1020
  • DOI: 10.1016/j.saa.2008.02.045