Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)
Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.
- Issue Date:
- OSTI Identifier:
- The Board of Regents of the University of Texas System ANL
- Patent Number(s):
- Application Number:
- Contract Number:
- Resource Relation:
- Patent File Date: 2013 Nov 14
- Research Org:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
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