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Title: Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)

Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.
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Issue Date:
OSTI Identifier:
The Board of Regents of the University of Texas System ANL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2013 Nov 14
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

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