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Title: Inhibition of HIF-2.alpha. heterodimerization with HIF1.beta. (ARNT)

Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.
Inventors:
; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1390247
Assignee:
The Board of Regents of the University of Texas System ANL
Patent Number(s):
9,757,379
Application Number:
14/442,485
Contract Number:
AC02-06CH11357
Resource Relation:
Patent File Date: 2013 Nov 14
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Works referenced in this record:

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