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Title: Compositions containing amino acids, phosphate and manganese and their uses

Abstract

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

Inventors:
;
Issue Date:
Research Org.:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1390218
Patent Number(s):
9758760
Application Number:
14/962,596
Assignee:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Dec 08
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Daly, Michael J., and Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States: N. p., 2017. Web.
Daly, Michael J., & Gaidamakova, Elena K. Compositions containing amino acids, phosphate and manganese and their uses. United States.
Daly, Michael J., and Gaidamakova, Elena K. Tue . "Compositions containing amino acids, phosphate and manganese and their uses". United States. https://www.osti.gov/servlets/purl/1390218.
@article{osti_1390218,
title = {Compositions containing amino acids, phosphate and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K.},
abstractNote = {The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 12 00:00:00 EDT 2017},
month = {Tue Sep 12 00:00:00 EDT 2017}
}

Works referenced in this record:

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Method and apparatus of a defined serumfree medical solution
patent, April 1995


Method of inactivation of viral and bacterial blood contaminants
patent, February 2001


Compositions containing amino acids, phosphate and manganese and their uses
patent, January 2016


Proteins having DNA repair promoting activity
patent-application, July 2003


Identification of essential genes in microorganisms
patent-application, February 2004


Vaccines Comprising Multimeric HSP60 Peptide Carriers
patent-application, October 2009


Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens
patent-application, July 2011


Compositions Containing Purine Nucleosides and Manganese and Their Uses
patent-application, July 2011


Vaccination with Irradiated Listeria Induces Protective T Cell Immunity
journal, July 2006


Death by protein damage in irradiated cells
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Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
journal, November 2004


Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
journal, September 2010


Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection
journal, August 2009


Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
journal, July 2012


Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans
journal, July 2010


A Manganese Porphyrin Complex is a Novel Radiation Protector
journal, July 2004


Potential Utility of Radioprotective Agents in the Practice of Nuclear Medicine
journal, December 2009


Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007