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Title: Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof

The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants and methods of producing lactic acids are also provided in various aspects of the invention.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1378093
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED GFO
Patent Number(s):
9,745,556
Application Number:
14/347,688
Contract Number:
FG36-04GO14019; FG36-08GO88142
Resource Relation:
Patent File Date: 2012 Oct 04
Research Org:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, Gainesville, FL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

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