Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof
Abstract
The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants and methods of producing lactic acids are also provided in various aspects of the invention.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Florida, Gainesville, FL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1377881
- Patent Number(s):
- 9745556
- Application Number:
- 14/347,688
- Assignee:
- University of Florida Research Foundation, Incorporated (Gainesville, FL)
- DOE Contract Number:
- FG36-04GO14019; FG36-08GO88142
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Oct 04
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Wang, Qingzhao, Shanmugam, Keelnatham T., and Ingram, Lonnie O'Neal. Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof. United States: N. p., 2017.
Web.
Wang, Qingzhao, Shanmugam, Keelnatham T., & Ingram, Lonnie O'Neal. Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof. United States.
Wang, Qingzhao, Shanmugam, Keelnatham T., and Ingram, Lonnie O'Neal. Tue .
"Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof". United States. https://www.osti.gov/servlets/purl/1377881.
@article{osti_1377881,
title = {Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof},
author = {Wang, Qingzhao and Shanmugam, Keelnatham T. and Ingram, Lonnie O'Neal},
abstractNote = {The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants and methods of producing lactic acids are also provided in various aspects of the invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {8}
}
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