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Title: Nucleic acid constructs containing orthogonal site selective recombinases (OSSRs)

The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each construct can, independently, further comprise one or more genes encoding a recombinase capable of recognizing the pair of recombinase recognition sequences of the construct. The recombinase can be an orthogonal (non-cross reacting), site-selective recombinase (OSSR).
Inventors:
; ;
Issue Date:
OSTI Identifier:
1377879
Assignee:
The Regents of the University of California LBNL
Patent Number(s):
9,745,587
Application Number:
13/088,288
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2011 Apr 15
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES