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Title: HIV-1 envelope glycoprotein

The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.
Inventors:
; ; ; ; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1376215
Assignee:
INTERNATIONAL AIDS VACCINE INITIATIVE ANL
Patent Number(s):
9,738,688
Application Number:
14/072,209
Contract Number:
AC02-06CH11357
Resource Relation:
Patent File Date: 2013 Nov 05
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Works referenced in this record:

Stabilization of the Soluble, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
journal, September 2002

Construction and Characterization of Soluble, Cleaved, and Stabilized Trimeric Env Proteins Based on HIV Type 1 Env Subtype A
journal, June 2006
  • Beddows, Simon; Kirschner, Marc; Campbell-Gardener, Lila
  • AIDS Research and Human Retroviruses, Vol. 22, Issue 6, p. 569-579
  • DOI: 10.1089/aid.2006.22.569

Identification of a clade A HIV envelope immunogen from Protocol G that elicits neutralizing antibodies to tier 2 viruses
journal, January 2012

Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
journal, July 2013
  • Klasse, P. J.; Depetris, R. S.; Pejchal, R.
  • Journal of Virology, Vol. 87, Issue 17, p. 9873-9885
  • DOI: 10.1128/JVI.01226-13

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
journal, June 2011
  • Melchers, Mark; Matthews, Katie; de Vries, Robert P.
  • Retrovirology, Vol. 8, Issue 1, Article No: 48
  • DOI: 10.1186/1742-4690-8-48

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
journal, September 2013