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Title: Acoustic concentration of particles in fluid flow

Disclosed herein is a acoustic concentration of particles in a fluid flow that includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.
Inventors:
;
Issue Date:
OSTI Identifier:
1375222
Assignee:
Los Alamos National Security, LLC LANL
Patent Number(s):
9,733,171
Application Number:
12/903,042
Contract Number:
AC51-06NA25396
Resource Relation:
Patent File Date: 2010 Oct 12
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Works referenced in this record:

Separation of lipids from blood utilizing ultrasonic standing waves in microfluidic channels
journal, January 2004
  • Petersson, Filip; Nilsson, Andreas; Holm, Cecilia
  • The Analyst, Vol. 129, Issue 10, p. 938-943
  • DOI: 10.1039/B409139F

Acoustic radiation potential on a sphere in plane, cylindrical, and spherical standing wave fields
journal, March 1985
  • Barmatz, M.; Collas, P.
  • The Journal of the Acoustical Society of America, Vol. 77, Issue 3, p. 928-945
  • DOI: 10.1121/1.392061

Improved quartz crystal microbalance technique
journal, August 1984
  • Benes, E.
  • Journal of Applied Physics, Vol. 56, Issue 3, p. 608-626
  • DOI: 10.1063/1.333990

Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy
journal, January 1990
  • Beverloo, H. B.; van Schadewijk, A.; van Gelderen-Boele, S.
  • Cytometry, Vol. 11, Issue 7, p. 784-792
  • DOI: 10.1002/cyto.990110704

Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis
journal, March 2006

Resolution of dimly fluorescent particles: A practical measure of fluorescence sensitivity
journal, October 1998

Impedance spectroscopy flow cytometry: On-chip label-free cell differentiation
journal, January 2005
  • Cheung, Karen; Gawad, Shady; Renaud, Philippe
  • Cytometry Part A, Vol. 65A, Issue 2, p. 124-132
  • DOI: 10.1002/cyto.a.20141

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation
journal, July 1994
  • Condrau, Marc A.; Schwendener, Reto A.; Niederer, Peter
  • Cytometry, Vol. 16, Issue 3, p. 187-194
  • DOI: 10.1002/cyto.990160302

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results
journal, July 1994
  • Condrau, Marc A.; Schwendener, Reto A.; Zimmermann, Marcel
  • Cytometry, Vol. 16, Issue 3, p. 195-205
  • DOI: 10.1002/cyto.990160303

Side drift of aerosols in two-dimensional resonant acoustic levitators
journal, November 1997
  • Dain, Y.
  • The Journal of the Acoustical Society of America, Vol. 102, Issue 5, p. 2549-2555
  • DOI: 10.1121/1.420309

Mean force on a small sphere in a sound field in a viscous fluid
journal, January 2000
  • Danilov, S. D.; Mironov, M. A.
  • The Journal of the Acoustical Society of America, Vol. 107, Issue 1, p. 143-153
  • DOI: 10.1121/1.428346

A Novel Ultrasonic Resonance Field Device for the Retention of Animal Cells
journal, July 1994
  • Doblhoff-Dier, O.; Gaida, Th.; Katinger, H.
  • Biotechnology Progress, Vol. 10, Issue 4, p. 428-432
  • DOI: 10.1021/bp00028a600

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. I. General formula
journal, February 1997
  • Doinikov, Alexander A.
  • The Journal of the Acoustical Society of America, Vol. 101, Issue 2, p. 713-721
  • DOI: 10.1121/1.418035

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. II. Force on a rigid sphere
journal, February 1997
  • Doinikov, Alexander A.
  • The Journal of the Acoustical Society of America, Vol. 101, Issue 2, p. 722-730
  • DOI: 10.1121/1.418036

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. III. Force on a liquid drop
journal, February 1997
  • Doinikov, Alexander A.
  • The Journal of the Acoustical Society of America, Vol. 101, Issue 2, p. 731-740
  • DOI: 10.1121/1.417961

Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid
journal, December 1994
  • Doinikov, A. A.
  • Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 447, Issue 1931, p. 447-466
  • DOI: 10.1098/rspa.1994.0150

Major signal increase in fluorescence microscopy through dark-state relaxation
journal, December 2006
  • Donnert, Gerald; Eggeling, Christian; Hell, Stefan W.
  • Nature Methods, Vol. 4, Issue 1, p. 81-86
  • DOI: 10.1038/nmeth986

Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging
journal, March 2006
  • Fenniri, Hicham; Terreau, Owen; Chun, Sangki
  • Journal of Combinatorial Chemistry, Vol. 8, Issue 2, p. 192-198
  • DOI: 10.1021/cc050128i

Selective Retention of Viable Cells in Ultrasonic Resonance Field Devices
journal, February 1996
  • Gaida, Th.; Doblhoff-Dier, O.; Strutzenberger, K.
  • Biotechnology Progress, Vol. 12, Issue 1, p. 73-76
  • DOI: 10.1021/bp950040k

Quantum Dot-Encoded Mesoporous Beads with High Brightness and Uniformity:  Rapid Readout Using Flow Cytometry
journal, April 2004
  • Gao, Xiaohu; Nie, Shuming
  • Analytical Chemistry, Vol. 76, Issue 8, p. 2406-2410
  • DOI: 10.1021/ac0354600

Single particle high resolution spectral analysis flow cytometry
journal, January 2006
  • Goddard, Gregory; Martin, John C.; Naivar, Mark
  • Cytometry Part A, Vol. 69A, Issue 8, p. 842-851
  • DOI: 10.1002/cyto.a.20320

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer
journal, January 2006
  • Goddard, Gregory; Martin, John C.; Graves, Steven W.
  • Cytometry Part A, Vol. 69A, Issue 2, p. 66-74
  • DOI: 10.1002/cyto.a.20205

Single-collector experiments and modeling of acoustically aided mesh filtration
journal, January 2005
  • Grossner, Michael T.; Feke, Donald L.; Belovich, Joanne M.
  • AIChE Journal, Vol. 51, Issue 6, p. 1590-1598
  • DOI: 10.1002/aic.10423

Contactless micromanipulation of small particles by an ultrasound field excited by a vibrating body
journal, May 2005
  • Haake, Albrecht; Dual, Jurg
  • The Journal of the Acoustical Society of America, Vol. 117, Issue 5, p. 2752-2760
  • DOI: 10.1121/1.1874592

Positioning, displacement, and localization of cells using ultrasonic forces
journal, January 2005
  • Haake, Albrecht; Neild, Adrian; Radziwill, Gerald
  • Biotechnology and Bioengineering, Vol. 92, Issue 1, p. 8-14
  • DOI: 10.1002/bit.20540

An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection
journal, January 2004
  • Habbersett, Robert C.; Jett, James H.
  • Cytometry, Vol. 60A, Issue 2, p. 125-134
  • DOI: 10.1002/cyto.a.20042

Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width
journal, January 2003
  • Hamilton, Mark F.; Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.
  • The Journal of the Acoustical Society of America, Vol. 113, Issue 1, p. 153-160
  • DOI: 10.1121/1.1528928

Linear and nonlinear frequency shifts in acoustical resonators with varying cross sections
journal, July 2001
  • Hamilton, Mark F.; Ilinskii, Yurii A.; Zabolotskaya, Evgenia A.
  • The Journal of the Acoustical Society of America, Vol. 110, Issue 1, p. 109-119
  • DOI: 10.1121/1.1379080

Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends
journal, July 2004
  • Harrison, Benjamin S.; Foley, Timothy J.; Knefely, Alison S.
  • Chemistry of Materials, Vol. 16, Issue 15, p. 2938-2947
  • DOI: 10.1021/cm049937f

Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results
journal, March 2002
  • Hawkes, Jeremy J.; Coakley, W. Terence; Gröschl, Martin
  • The Journal of the Acoustical Society of America, Vol. 111, Issue 3, p. 1259-1266
  • DOI: 10.1121/1.1448341

Standing‐wave acoustic trap for nonintrusive positioning of microparticles
journal, October 1995
  • Hertz, H. M.
  • Journal of Applied Physics, Vol. 78, Issue 8, p. 4845-4849
  • DOI: 10.1063/1.359770

The selection of layer thicknesses to control acoustic radiation force profiles in layered resonators
journal, January 2003
  • Hill, Martyn
  • The Journal of the Acoustical Society of America, Vol. 114, Issue 5, Article No. 2654
  • DOI: 10.1121/1.1616581

Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels
journal, April 2005
  • Huhtinen, Petri; Kivelä, Mirja; Kuronen, Outi
  • Analytical Chemistry, Vol. 77, Issue 8, p. 2643-2648
  • DOI: 10.1021/ac048360i

Coincidence in high-speed flow cytometry: Models and measurements
journal, January 1991
  • Keij, Jan F.; Rotterdam, Ab Van; Groenewegen, Ad C.
  • Cytometry, Vol. 12, Issue 5, p. 398-404
  • DOI: 10.1002/cyto.990120504

Enhanced sedimentation of mammalian cells following acoustic aggregation
journal, August 1989
  • Kilburn, D. G.; Clarke, D. J.; Coakley, W. T.
  • Biotechnology and Bioengineering, Vol. 34, Issue 4, p. 559-562
  • DOI: 10.1002/bit.260340415

Acoustic concentration of particles in piezoelectric tubes: Theoretical modeling of the effect of cavity shape and symmetry breaking
journal, October 2004
  • Kogan, Shulim; Kaduchak, Gregory; Sinha, Dipen N.
  • The Journal of the Acoustical Society of America, Vol. 116, Issue 4, p. 1967-1974
  • DOI: 10.1121/1.1785613

Micromanipulation using a focused ultrasonic standing wave field
journal, January 2000

Fractionation of cell mixtures using acoustic and laminar flow fields
journal, January 2004
  • Kumar, Manoj; Feke, Donald L.; Belovich, Joanne M.
  • Biotechnology and Bioengineering, Vol. 89, Issue 2, p. 129-137
  • DOI: 10.1002/bit.20294

Cavitation bubble-driven cell and particle behavior in an ultrasound standing wave
journal, January 2005
  • Kuznetsova, Larisa A.; Khanna, Sanjay; Amso, Nazar N.
  • The Journal of the Acoustical Society of America, Vol. 117, Issue 1, p. 104-112
  • DOI: 10.1121/1.1835503

Microparticle concentration in short path length ultrasonic resonators: Roles of radiation pressure and acoustic streaming
journal, October 2004
  • Kuznetsova, Larisa A.; Coakley, W. Terence
  • The Journal of the Acoustical Society of America, Vol. 116, Issue 4, p. 1956-1966
  • DOI: 10.1121/1.1785831

Resonator frequency shift due to ultrasonically induced microparticle migration in an aqueous suspension: Observations and model for the maximum frequency shift
journal, June 1998
  • Kwiatkowski, Christopher S.; Marston, Philip L.
  • The Journal of the Acoustical Society of America, Vol. 103, Issue 6, p. 3290-3300
  • DOI: 10.1121/1.423080

Increasing the luminescence of lanthanide complexes
journal, January 2006
  • Leif, Robert C.; Vallarino, Lidia M.; Becker, Margie C.
  • Cytometry Part A, Vol. 69A, Issue 8, p. 767-778
  • DOI: 10.1002/cyto.a.20321

Theory of long wavelength acoustic radiation pressure
journal, October 1991
  • Löfstedt, Ritva; Putterman, Seth
  • The Journal of the Acoustical Society of America, Vol. 90, Issue 4, p. 2027-2033
  • DOI: 10.1121/1.401630

Scanning flow cytometry for individual particle analysis
journal, January 2000
  • Maltsev, Valeri P.
  • Review of Scientific Instruments, Vol. 71, Issue 1, p. 243-255
  • DOI: 10.1063/1.1150190

Manipulation of Fluid Objects with Acoustic Radiation Pressure
journal, January 2006
  • Marston, Philip L.; Thiessen, David B.
  • Annals of the New York Academy of Sciences, Vol. 1027, Issue 1, p. 414-434
  • DOI: 10.1196/annals.1324.034

Particle Characterization and Separation by a Coupled Acoustic−Gravity Field
journal, July 2001
  • Masudo, Takashi; Okada, Tetsuo
  • Analytical Chemistry, Vol. 73, Issue 14, p. 3467-3471
  • DOI: 10.1021/ac001354b

Single particle aerodynamic relaxation time analyzer
journal, June 1977
  • Mazumder, M. K.; Kirsch, K. J.
  • Review of Scientific Instruments, Vol. 48, Issue 6, p. 622-624
  • DOI: 10.1063/1.1135094

Acoustic control of suspended particles in micro fluidic chips
journal, January 2004
  • Nilsson, Andreas; Petersson, Filip; Jönsson, Henrik
  • Lab Chip, Vol. 4, Issue 2, p. 131-135
  • DOI: 10.1039/B313493H

Layered piezoelectric resonators with an arbitrary number of electrodes (general one‐dimensional treatment)
journal, September 1991
  • Nowotny, Helmut; Benes, Ewald; Schmid, Michael
  • The Journal of the Acoustical Society of America, Vol. 90, Issue 3, p. 1238-1245
  • DOI: 10.1121/1.401915

Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels
journal, March 2005
  • Petersson, Filip; Nilsson, Andreas; Jönsson, Henrik
  • Analytical Chemistry, Vol. 77, Issue 5, p. 1216-1221
  • DOI: 10.1021/ac048394q

Free Flow Acoustophoresis:  Microfluidic-Based Mode of Particle and Cell Separation
journal, July 2007
  • Petersson, Filip; Åberg, Lena; Swärd-Nilsson, Ann-Margret
  • Analytical Chemistry, Vol. 79, Issue 14, p. 5117-5123
  • DOI: 10.1021/ac070444e

Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis
journal, March 2007
  • Pregibon, Daniel C.; Toner, Mehmet; Doyle, Patrick S.
  • Science, Vol. 315, Issue 5817, p. 1393-1396
  • DOI: 10.1126/science.1134929

Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry
journal, December 2002
  • Princen, Katrien; Hatse, Sigrid; Vermeire, Kurt
  • Cytometry, Vol. 51A, Issue 1, p. 35-45
  • DOI: 10.1002/cyto.a.10008

Monodisperse Mesoporous Silica Microspheres Formed by Evaporation-Induced Self Assembly of Surfactant Templates in Aerosols
journal, September 2002

A novel nozzle for more efficient sperm orientation to improve sorting efficiency of X and Y chromosome-bearing sperm
journal, December 1998

A numerically stable global matrix method for cylindrically layered shells excited by ring forces
journal, June 1994
  • Ricks, David C.; Schmidt, Henrik
  • The Journal of the Acoustical Society of America, Vol. 95, Issue 6, p. 3339-3349
  • DOI: 10.1121/1.409953

Oscillational instabilities in single‐mode acoustic levitators
journal, January 1990
  • Rudnick, Joseph; Barmatz, M.
  • The Journal of the Acoustical Society of America, Vol. 87, Issue 1, p. 81-92
  • DOI: 10.1121/1.398916

Ultrasonic manipulation of locomotive microorganisms and evaluation of their activity
journal, December 2002
  • Saito, Mitsunori; Kitamura, Norio; Terauchi, Masaki
  • Journal of Applied Physics, Vol. 92, Issue 12, p. 7581-7586
  • DOI: 10.1063/1.1522813

Ultrasonic trapping of paramecia and estimation of their locomotive force
journal, October 1997
  • Saito, Mitsunori; Izumida, Shin-ya; Hirota, Jun
  • Applied Physics Letters, Vol. 71, Issue 14, p. 1909-1911
  • DOI: 10.1063/1.120436

Ultrasonic waves for fabricating lattice structure in composite materials
conference, September 1999
  • Saito, Mitsunori; Itagaki, Kazuhiro; Imanishi, Yoshihiro
  • SPIE's International Symposium on Optical Science, Engineering, and Instrumentation
  • DOI: 10.1117/12.363793

Continuous Flow Microfluidic Device for Rapid Erythrocyte Lysis
journal, November 2004
  • Sethu, Palaniappan; Anahtar, Melis; Moldawer, Lyle L.
  • Analytical Chemistry, Vol. 76, Issue 21, p. 6247-6253
  • DOI: 10.1021/ac049429p

Individual Escherichia coli cells studied from light scattering with the scanning flow cytometer
journal, January 2000

Ultrasonic four‐wave mixing mediated by an aqueous suspension of microspheres: Theoretical steady‐state properties
journal, September 1995
  • Simpson, Harry J.; Marston, Philip L.
  • The Journal of the Acoustical Society of America, Vol. 98, Issue 3, p. 1731-1741
  • DOI: 10.1121/1.413437

New types of microspheres and microsphere-related materials for medical diagnostics
journal, October 2002
  • Slomkowski, Stanislaw; Basinska, Teresa; Miksa, Beata
  • Polymers for Advanced Technologies, Vol. 13, Issue 10-12, p. 905-918
  • DOI: 10.1002/pat.283

Dual-laser, differential fluorescence correction method for reducing cellular background autofluorescence
journal, November 1986

A differential amplifier circuit for reducing noise in axial light loss measurements
journal, July 1983

Resolving leukocytes using axial light loss
journal, July 1989
  • Stewart, Carleton C.; Stewart, Sigrid J.; Habbersett, Robert C.
  • Cytometry, Vol. 10, Issue 4, p. 426-432
  • DOI: 10.1002/cyto.990100410

Data Analysis for a Dual-Channel Virus Counter
journal, April 2005
  • Stoffel, Carrie L.; Rowlen, Kathy L.
  • Analytical Chemistry, Vol. 77, Issue 7, p. 2243-2246
  • DOI: 10.1021/ac048626l

Design and characterization of a compact dual channel virus counter
journal, January 2005
  • Stoffel, Carrie L.; Kathy, Robin Finch; Rowlen, Kathy L.
  • Cytometry Part A, Vol. 65A, Issue 2, p. 140-147
  • DOI: 10.1002/cyto.a.20145

Separation devices based on forced coincidence response of fluid‐filled pipes
journal, June 1992
  • Tolt, Thomas L.; Feke, Donald L.
  • The Journal of the Acoustical Society of America, Vol. 91, Issue 6, p. 3152-3156
  • DOI: 10.1121/1.402853

Experimental study of streaming flows associated with ultrasonic levitators
journal, November 1994
  • Trinh, E. H.; Robey, J. L.
  • Physics of Fluids, Vol. 6, Issue 11, p. 3567-3579
  • DOI: 10.1063/1.868415

Compact acoustic levitation device for studies in fluid dynamics and material science in the laboratory and microgravity
journal, November 1985
  • Trinh, E. H.
  • Review of Scientific Instruments, Vol. 56, Issue 11, p. 2059-2065
  • DOI: 10.1063/1.1138419

Ruthenium(II) complex with a notably long excited state lifetime
journal, January 2000
  • Tyson, Daniel S.; Bialecki, Jason; Castellano, Felix N.
  • Chemical Communications, Vol. 0, Issue 23, p. 2355-2356
  • DOI: 10.1039/B007336I

Strategy for selection of methods for separation of bioparticles from particle mixtures
journal, January 2006
  • van Hee, P.; Hoeben, M. A.; van der Lans, R. G. J. M.
  • Biotechnology and Bioengineering, Vol. 94, Issue 4, p. 689-709
  • DOI: 10.1002/bit.20885

Focus: Beads and chips: new recipes for analysis
journal, October 2003
  • Verpoorte, Elisabeth
  • Lab on a Chip, Vol. 3, Issue 4, p. 60N-68N
  • DOI: 10.1039/B313217J

Retention and Viability Characteristics of Mammalian Cells in an Acoustically Driven Polymer Mesh
journal, January 2004
  • Wang, Zhaowei; Grabenstetter, Paul; Feke, Donald L.
  • Biotechnology Progress, Vol. 20, Issue 1, p. 384-387
  • DOI: 10.1021/bp034105s

Extension of acoustic levitation to include the study of micron‐size particles in a more compressible host liquid
journal, May 1982
  • Weiser, Mary Ann H.; Apfel, Robert E.
  • The Journal of the Acoustical Society of America, Vol. 71, Issue 5, p. 1261-1268
  • DOI: 10.1121/1.387776

Particle column formation in a stationary ultrasonic field
journal, January 1992
  • Whitworth, Glenn; Coakley, W. T.
  • The Journal of the Acoustical Society of America, Vol. 91, Issue 1, p. 79-85
  • DOI: 10.1121/1.402622

Diazo Coupling Method for Covalent Attachment of Proteins to Solid Substrates
journal, March 2006
  • Wu, Yang; Buranda, Tione; Metzenberg, Robert L.
  • Bioconjugate Chemistry, Vol. 17, Issue 2, p. 359-365
  • DOI: 10.1021/bc050278m

Flow cytometry to evaluate Theileria sergenti parasitemia using the fluorescent nucleic acid stain, SYTO16
journal, January 2000

Deoxyribonucleic acid concentration using acoustic radiation force
journal, February 1996
  • Yasuda, Kenji; Kiyama, Masaharu; Umemura, Shin‐ichiro
  • The Journal of the Acoustical Society of America, Vol. 99, Issue 2, p. 1248-1251
  • DOI: 10.1121/1.414635

Particle separation using acoustic radiation force and elecrostatic force
journal, April 1996
  • Yasuda, Kenji; Umemura, Shin‐ichiro; Takeda, Kazuo
  • The Journal of the Acoustical Society of America, Vol. 99, Issue 4, p. 1965-1970
  • DOI: 10.1121/1.415382

Using acoustic radiation force as a concentration method for erythrocytes
journal, July 1997
  • Yasuda, Kenji; Haupt, Stephan Shuichi; Umemura, Shin-ichiro
  • The Journal of the Acoustical Society of America, Vol. 102, Issue 1, p. 642-645
  • DOI: 10.1121/1.421009