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Title: Cells and methods for producing fatty alcohols

Abstract

Recombinant cells and methods for improved yield of fatty alcohols. The recombinant cells harbor a recombinant thioesterase gene, a recombinant acyl-CoA synthetase gene, and a recombinant acyl-CoA reductase gene. In addition, a gene product from one or more of an acyl-CoA dehydrogenase gene, an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase gene, and a 3-ketoacyl-CoA thiolase gene in the recombinant cells is functionally deleted. Culturing the recombinant cells produces fatty alcohols at high yields.

Inventors:
;
Issue Date:
Research Org.:
WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1371919
Patent Number(s):
9708630
Application Number:
14/509,408
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
FC02-07ER64494
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Oct 08
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Pfleger, Brian F., and Youngquist, Tyler J. Cells and methods for producing fatty alcohols. United States: N. p., 2017. Web.
Pfleger, Brian F., & Youngquist, Tyler J. Cells and methods for producing fatty alcohols. United States.
Pfleger, Brian F., and Youngquist, Tyler J. Tue . "Cells and methods for producing fatty alcohols". United States. https://www.osti.gov/servlets/purl/1371919.
@article{osti_1371919,
title = {Cells and methods for producing fatty alcohols},
author = {Pfleger, Brian F. and Youngquist, Tyler J.},
abstractNote = {Recombinant cells and methods for improved yield of fatty alcohols. The recombinant cells harbor a recombinant thioesterase gene, a recombinant acyl-CoA synthetase gene, and a recombinant acyl-CoA reductase gene. In addition, a gene product from one or more of an acyl-CoA dehydrogenase gene, an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase gene, and a 3-ketoacyl-CoA thiolase gene in the recombinant cells is functionally deleted. Culturing the recombinant cells produces fatty alcohols at high yields.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {7}
}

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