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Title: Spatial biomarker of disease and detection of spatial organization of cellular receptors

Abstract

A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1371905
Patent Number(s):
9708665
Application Number:
The Regents of the University of California
Assignee:
The Regents of the University of California
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Jul 29
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Salaita, Khalid S., Nair, Pradeep M., Das, Debopriya, Gray, Joe W., and Groves, John T. Spatial biomarker of disease and detection of spatial organization of cellular receptors. United States: N. p., 2017. Web.
Salaita, Khalid S., Nair, Pradeep M., Das, Debopriya, Gray, Joe W., & Groves, John T. Spatial biomarker of disease and detection of spatial organization of cellular receptors. United States.
Salaita, Khalid S., Nair, Pradeep M., Das, Debopriya, Gray, Joe W., and Groves, John T. Tue . "Spatial biomarker of disease and detection of spatial organization of cellular receptors". United States. https://www.osti.gov/servlets/purl/1371905.
@article{osti_1371905,
title = {Spatial biomarker of disease and detection of spatial organization of cellular receptors},
author = {Salaita, Khalid S. and Nair, Pradeep M. and Das, Debopriya and Gray, Joe W. and Groves, John T.},
abstractNote = {A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {7}
}

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