Title: Spatial biomarker of disease and detection of spatial organization of cellular receptors

Abstract

A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.

Inventors:

Salaita, Khalid S.; Nair, Pradeep M.; Das, Debopriya; Gray, Joe W.; Groves, John T.

Issue Date:

2017-07-18

Research Org.:

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1371905

Patent Number(s):

9,708,665

Application Number:

The Regents of the University of California

Assignee:

The Regents of the University of California

DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Resource Relation:

Patent File Date: 2011 Jul 29

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES