System and method for detecting components of a mixture including a valving scheme for competition assays
Abstract
Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1369070
- Patent Number(s):
- 9702871
- Application Number:
- 14/546,876
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Nov 18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K. System and method for detecting components of a mixture including a valving scheme for competition assays. United States: N. p., 2017.
Web.
Koh, Chung-Yan, Piccini, Matthew E., & Singh, Anup K. System and method for detecting components of a mixture including a valving scheme for competition assays. United States.
Koh, Chung-Yan, Piccini, Matthew E., and Singh, Anup K. Tue .
"System and method for detecting components of a mixture including a valving scheme for competition assays". United States. https://www.osti.gov/servlets/purl/1369070.
@article{osti_1369070,
title = {System and method for detecting components of a mixture including a valving scheme for competition assays},
author = {Koh, Chung-Yan and Piccini, Matthew E. and Singh, Anup K.},
abstractNote = {Examples are described including measurement systems for conducting competition assays. A first chamber of an assay device may be loaded with a sample containing a target antigen. The target antigen in the sample may be allowed to bind to antibody-coated beads in the first chamber. A control layer separating the first chamber from a second chamber may then be opened to allow a labeling agent loaded in a first portion of the second chamber to bind to any unoccupied sites on the antibodies. A centrifugal force may then be applied to transport the beads through a density media to a detection region for measurement by a detection unit.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {7}
}
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