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Title: System and method for measuring fluorescence of a sample

The present disclosure provides a system and a method for measuring fluorescence of a sample. The sample may be a polymerase-chain-reaction (PCR) array, a loop-mediated-isothermal amplification array, etc. LEDs are used to excite the sample, and a photodiode is used to collect the sample's fluorescence. An electronic offset signal is used to reduce the effects of background fluorescence and the noises from the measurement system. An integrator integrates the difference between the output of the photodiode and the electronic offset signal over a given period of time. The resulting integral is then converted into digital domain for further processing and storage.
Inventors:
Issue Date:
OSTI Identifier:
1366507
Assignee:
Lawrence Livermore National Security, LLC LLNL
Patent Number(s):
9,689,799
Application Number:
14/602,076
Contract Number:
AC52-07NA27344
Resource Relation:
Patent File Date: 2015 Jan 21
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

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