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Title: Enhanced processive cellulases

Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.
Inventors:
; ; ; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1364629
Assignee:
Alliance for Sustainable Energy, LLC NREL
Patent Number(s):
9,683,248
Application Number:
14/365,200
Contract Number:
AC36-08G028308
Resource Relation:
Patent File Date: 2012 Dec 17
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

A family of thermostable fungal cellulases created by structure-guided recombination
journal, March 2009
  • Heinzelman, P.; Snow, C. D.; Wu, I.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 14, p. 5610-5615
  • DOI: 10.1073/pnas.0901417106

SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability
journal, July 2009
  • Heinzelman, Pete; Snow, Christopher D.; Smith, Matthew A.
  • Journal of Biological Chemistry, Vol. 284, Issue 39, p. 26229-26233
  • DOI: 10.1074/jbc.C109.034058

Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source
journal, July 2010
  • Kim, Tae-Wan; Chokhawala, Harshal A.; Nadler, Dana
  • Biotechnology and Bioengineering, Vol. 107, Issue 4, p. 601-611
  • DOI: 10.1002/bit.22856