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Title: Enhanced processive cellulases

Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.
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Issue Date:
OSTI Identifier:
Alliance for Sustainable Energy, LLC NREL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2012 Dec 17
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org:
Country of Publication:
United States

Other works cited in this record:

Method for analyzing and synthesizing functional polypeptide sequences for assembly into enhanced or multi-functional proteins
patent, August 1990

Superactive cellulase formulation using cellobiohydrolase-1 from Penicillium funiculosum
patent, November 2008

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
patent, October 2011

Polypeptides having endoglucanase activity and polynucleotides encoding same
patent, November 2011

A family of thermostable fungal cellulases created by structure-guided recombination
journal, March 2009
  • Heinzelman, P.; Snow, C. D.; Wu, I.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 14, p. 5610-5615
  • DOI: 10.1073/pnas.0901417106

SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability
journal, July 2009
  • Heinzelman, Pete; Snow, Christopher D.; Smith, Matthew A.
  • Journal of Biological Chemistry, Vol. 284, Issue 39, p. 26229-26233
  • DOI: 10.1074/jbc.C109.034058

Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source
journal, July 2010
  • Kim, Tae-Wan; Chokhawala, Harshal A.; Nadler, Dana
  • Biotechnology and Bioengineering, Vol. 107, Issue 4, p. 601-611
  • DOI: 10.1002/bit.22856

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