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Title: Graphene-based field-effect transistor biosensors

The disclosure provides a field-effect transistor (FET)-based biosensor and uses thereof. In particular, to FET-based biosensors using thermally reduced graphene-based sheets as a conducting channel decorated with nanoparticle-biomolecule conjugates. The present disclosure also relates to FET-based biosensors using metal nitride/graphene hybrid sheets. The disclosure provides a method for detecting a target biomolecule in a sample using the FET-based biosensor described herein.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1363769
Assignee:
UWM Research Foundation, Inc. DOEEE
Patent Number(s):
9,676,621
Application Number:
13/399,288
Contract Number:
EE003208
Resource Relation:
Patent File Date: 2012 Feb 17
Research Org:
UWM Research Foundation, Inc. Milwaukee, WI (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

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Importance of Controlling Nanotube Density for Highly Sensitive and Reliable Biosensors Functional in Physiological Conditions
journal, October 2010
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  • ACS Nano, Vol. 4, Issue 11, p. 6914-6922
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Channel-Length-Dependent Field-Effect Mobility and Carrier Concentration of Reduced Graphene Oxide Thin-Film Transistors
journal, May 2010
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Universal Parameters for Carbon Nanotube Network-Based Sensors: Can Nanotube Sensors Be Reproducible?
journal, May 2011
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  • ACS Nano, Vol. 5, Issue 6, p. 4373-4379
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Lead(II)-Induced Allosteric G-Quadruplex DNAzyme as a Colorimetric and Chemiluminescence Sensor for Highly Sensitive and Selective Pb2+ Detection
journal, February 2010
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Reduced Graphene Oxide Electrically Contacted Graphene Sensor for Highly Sensitive Nitric Oxide Detection
journal, August 2011
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  • ACS Nano, Vol. 5, Issue 9, p. 6955-6961
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Stimuli-Responsive Disassembly of Nanoparticle Aggregates for Light-Up Colorimetric Sensing
journal, September 2005
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Room-Temperature Gas Sensing Based on Electron Transfer between Discrete Tin Oxide Nanocrystals and Multiwalled Carbon Nanotubes
journal, June 2009
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  • Advanced Materials, Vol. 21, Issue 24, p. 2487-2491
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Boron Doped Diamond Biosensor for Detection of Escherichia coli
journal, September 2008
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  • Journal of Agricultural and Food Chemistry, Vol. 56, Issue 17, p. 7691-7695
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Improved Synthesis of Graphene Oxide
journal, July 2010
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  • ACS Nano, Vol. 4, Issue 8, p. 4806-4814
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Single Sheet Functionalized Graphene by Oxidation and Thermal Expansion of Graphite
journal, September 2007
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Ultrasensitive Pb 2+ Detection by Glutathione-Capped Quantum Dots
journal, December 2007
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  • Analytical Chemistry, Vol. 79, Issue 24, p. 9452-9458
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Detection of Trace Heavy Metal Ions Using Carbon Nanotube- Modified Electrodes
journal, July 2009
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  • Electroanalysis, Vol. 21, Issue 14, p. 1597-1603
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Graphene: The New Two-Dimensional Nanomaterial
journal, October 2009
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Water Analysis: Emerging Contaminants and Current Issues
journal, June 2009
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Wafer-scale Reduced Graphene Oxide Films for Nanomechanical Devices
journal, October 2008
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  • Nano Letters, Vol. 8, Issue 10, p. 3441-3445
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Development of a Sensitive Detection Method for Stressed E. coli O157:H7 in Source and Finished Drinking Water by Culture-qPCR
journal, March 2011
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  • Environmental Science & Technology, Vol. 45, Issue 6, p. 2250-2256
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Gold Nanorod Based Selective Identification of Escherichia coli Bacteria Using Two-Photon Rayleigh Scattering Spectroscopy
journal, June 2009
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  • ACS Nano, Vol. 3, Issue 7, p. 1906-1912
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Electrical Detection of Metal Ions Using Field-Effect Transistors Based on Micropatterned Reduced Graphene Oxide Films
journal, February 2011
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  • ACS Nano, Vol. 5, Issue 3, p. 1990-1994
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Immobilization of a Catalytic DNA Molecular Beacon on Au for Pb(II) Detection
journal, January 2005
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Biomolecule-Assisted Synthesis of Water-Soluble Silver Nanoparticles and Their Biomedical Applications
journal, July 2008
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  • Inorganic Chemistry, Vol. 47, Issue 13, p. 5882-5888
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Graphene Field-Effect Transistors with High On/Off Current Ratio and Large Transport Band Gap at Room Temperature
journal, February 2010
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  • Nano Letters, Vol. 10, Issue 2, p. 715-718
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A Review on Functionalized Gold Nanoparticles for Biosensing Applications
journal, April 2011

Self-Assembled 1-Octadecanethiol Monolayers on Graphene for Mercury Detection
journal, November 2010
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  • Nano Letters, Vol. 10, Issue 11, p. 4738-4741
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Graphene–DNAzyme Based Biosensor for Amplified Fluorescence “Turn-On” Detection of Pb 2+ with a High Selectivity
journal, July 2011
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  • Analytical Chemistry, Vol. 83, Issue 13, p. 5062-5066
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Graphene and Graphene Oxide: Synthesis, Properties, and Applications
journal, June 2010
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